Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2025; 17(7): 107259
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.107259
Targeting probiotic modulation of gut microbiota for postoperative depression management in patients undergoing gastric cancer surgery
Yao Peng, Man-Ying Xie, Ling Gan, Jia-Qi Zhang
Yao Peng, Ling Gan, Jia-Qi Zhang, Department of Ultrasound Imaging, Postgraduate Union Training Base of Xiangyang No. 1 People's Hospital, Xiangyang 441000, Hubei Province, China
Yao Peng, Ling Gan, Jia-Qi Zhang, School of Medicine, Wuhan University of Science and Technology, Xiangyang 441100, Hubei Province, China
Man-Ying Xie, Department of Ultrasound, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang 441000, Hubei Province, China
Co-first authors: Yao Peng and Man-Ying Xie.
Co-corresponding authors: Ling Gan and Jia-Qi Zhang.
Author contributions: Zhang JQ contributed to the writing, editing of the manuscript and table; Peng Y contributed to the discussion and design of the manuscript; Xie MY contributed to the literature search; Gan L designed the overall concept and outline of the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Qi Zhang, Associate Professor, MD, PhD, Department of Ultrasound Imaging, Xiangyang No. 1 People's Hospital, No. 15 Jiefang Road, Fancheng District, Xiangyang 441000, Hubei Province, China. 347235272@qq.com
Received: March 19, 2025
Revised: April 3, 2025
Accepted: May 20, 2025
Published online: July 27, 2025
Processing time: 126 Days and 18.8 Hours
Core Tip

Core Tip: Post-gastric cancer surgery, depression critically impacts recovery. Combining Bifidobacterium triple viable bacteria with mirtazapine reduced Self-Rating Depression Scale depression scores by 32%, improved neuroendocrine markers, and modulated gut microbiota. Integrating these interventions with psychological support and lifestyle changes optimizes patient adaptation and long-term well-being.