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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2025; 17(7): 106672
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.106672
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.106672
Acellular mucin in neoplastic and non-neoplastic conditions of the lower gastrointestinal tract
Noureldien Darwish, Lynn Guo, Eundong Park, Hwajeong Lee, Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United States
Author contributions: Darwish N and Guo L wrote the original draft; Park E reviewed and edited the original draft; Lee H conceptualized the work, provided guidance, reviewed and edited the original draft; All authors read and approved the final version.
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hwajeong Lee, MD, Professor, Department of Pathology and Laboratory Medicine, Albany Medical Center, 43 New Scotland Ave, Albany, NY 12208, United States. leeh5@amc.edu
Received: March 4, 2025
Revised: April 3, 2025
Accepted: May 22, 2025
Published online: July 27, 2025
Processing time: 141 Days and 17.1 Hours
Revised: April 3, 2025
Accepted: May 22, 2025
Published online: July 27, 2025
Processing time: 141 Days and 17.1 Hours
Core Tip
Core Tip: Acellular mucin in both neoplastic and non-neoplastic lower gastrointestinal tract conditions may complicate diagnosis, prognostication and management. In colorectal and appendiceal mucinous neoplasms, it plays a role in tumor classification and staging. In non-neoplastic conditions, the presence of acellular mucin and related epithelial changes may mimic neoplasm and lead to additional work-up. This review highlights the diagnostic and prognostic implications of acellular mucin in neoplastic and non-neoplastic conditions, emphasizing the need for standardized approaches to improve pathological interpretation and management.