Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 106813
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.106813
Role of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios in rectal cancer prognosis
Li-Li Shao, Xiang Li, Li-Fen Wang
Li-Li Shao, Xiang Li, Li-Fen Wang, Clinical Laboratory, Changzhi People’s Hospital of Shanxi Province, Changzhi 046000, Shanxi Province, China
Author contributions: Shao LL designed the study; Shao LL, Li X, and Wang LF contributed to the analysis of the manuscript, the data collection, and the writing of this article; All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of the Changzhi People’s Hospital of Shanxi Province (No. 2024K057).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Li Shao, Associate Chief Physician, Clinical Laboratory, Changzhi People’s Hospital of Shanxi Province, No. 502 Changxing Middle Road, Changzhi 046000, Shanxi Province, China. shaolili001@126.com
Received: March 7, 2025
Revised: March 31, 2025
Accepted: May 6, 2025
Published online: June 27, 2025
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Core Tip

Core Tip: This retrospective study of 180 patients with rectal cancer revealed that combined assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio provided superior prognostic value compared with individual ratios. Post-surgery neutrophil-to-lymphocyte/platelet-to-lymphocyte/monocyte-to-lymphocyte ratio levels showed significant discriminative power (area under the curve = 0.828) with 89.29% sensitivity and 90.79% specificity for predicting poor outcomes. The dynamic reduction of inflammatory ratios in responders highlighted their clinical utility for postoperative monitoring and risk stratification.