Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 104923
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.104923
Clinical significance of immune cell and biomarker changes in liver cancer
Su-Tao Zhou, Bin Zhang, Ke Ma, Juan Guo
Su-Tao Zhou, Bin Zhang, Ke Ma, Juan Guo, Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei Province, China
Author contributions: Zhou ST contributed to the conception and design of the study, as well as the data acquisition and analysis; Zhang B, Ma K, and Guo J assisted with the data collection; Zhou ST and Zhang B analyzed the data and wrote the manuscript; All authors read and approved the final version.
Institutional review board statement: This study was approved by the Ethics Committee of The First Affiliated Hospital of Hebei North University (No. K2025001).
Informed consent statement: The data used in this study were not involved in the patients’ privacy information, so the informed consent was waived by the Ethics Committee of The First Affiliated Hospital of Hebei North University.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Su-Tao Zhou, Department of Laboratory Medicine, The First Affiliated Hospital of Hebei North University, No. 12 Changqing Road, Zhangjiakou 075000, Hebei Province, China. zjkzhousutao@163.com
Received: February 12, 2025
Revised: March 13, 2025
Accepted: May 6, 2025
Published online: June 27, 2025
Processing time: 107 Days and 3.2 Hours
Core Tip

Core Tip: This investigation determined cluster of differentiation 4-positive (CD4+), CD8+, CD3+CD56+, CD8+CD56+, CD3+CD161+, and CD3-CD161+ natural killer T (NKT) cell, alpha fetoprotein (AFP), and gamma-glutamyl transpeptidase (GGT) levels in the peripheral blood samples of patients with primary liver cancer (PLC) and healthy individuals. The aim was to confirm the diagnostic value of NKT cell subsets, AFP, and GGT levels in the context of PLC. The results revealed a marked increase in the levels of CD8+CD56+NKT, CD3+CD161+NKT, CD3-CD161+NKT, AFP, and GGT in patients with PLC. Combining these five indicators for detection enhances the sensitivity and specificity of PLC diagnosis.