Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 104505
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.104505
Relationship between prognosis and glucose transporter-1 and Ki-67 expression in obstructive colon cancer pre and post stent placement
Kun-Ning Zhang, Mu-Lan Jin, Zhi-Wei Zhai
Kun-Ning Zhang, Mu-Lan Jin, Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Zhi-Wei Zhai, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Co-corresponding authors: Mu-Lan Jin and Zhi-Wei Zhai.
Author contributions: Jin ML and Zhai ZW contributed equally to the study and as co- corresponding authors of this manuscript; Zhang KN contributed to original draft preparation, writing, and review; Jin ML contributed to conceptualization, supervision, and immunohistochemical analyses; Zhai ZW contributed to conceptualization, supervision, and statistical analysis; and all authors have read and agreed to the published version of the manuscript. In this study, stent implantation and surgical treatment were performed in the Department of General Surgery, whereas tumor pathological diagnosis and immunohistochemical analysis were conducted in the Department of Pathology. This research required collaborative efforts between the two departments to be completed successfully; neither department could have accomplished it independently. Zhai ZW and Jin ML jointly designed the study, analyzed the research results, and provided supervision and management throughout the entire process to ensure its smooth progression. Zhai ZW and Jin ML are jointly responsibility for the authenticity of the research findings and declare that there is no conflict of interest. Given their equal contributions to this work, they should be recognized as co-corresponding authors.
Institutional review board statement: This study was approved by the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University (2016-ke-161).
Informed consent statement: Informed consent was obtained from all patients before treatment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Wei Zhai, Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing 100020, China. zhiweizhai@ccmu.edu.cn
Received: December 27, 2024
Revised: April 21, 2025
Accepted: May 14, 2025
Published online: June 27, 2025
Processing time: 154 Days and 21.7 Hours
Core Tip

Core Tip: Self-expanding metallic stent placement is becoming a more common treatment approach for obstructive left-sided colon cancer, there is still ongoing debate regarding its long-term impact on patient prognosis. Stent expansion can result in the compression of blood vessels within the tumor due to mechanical pressure, may induce changes in the tumor microenvironment, potentially affecting patient prognosis. Our study found an increase in glucose transporter-1 (GLUT-1) expression in tumor tissues after self-expanding metallic stent placement. Tumor GLUT-1 serves as a prognostic biomarker for the survival of patients with obstructive colon cancer treated with self-expanding metallic stent placement.