Effectiveness of early enteral nutrition support in patients undergoing gastrointestinal perforation repair surgery within the enhanced recovery

doi:10.4240/wjgs.v17.i5.106384

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May 27, 2025 (publication date) through May 23, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastrointest Surg. May 27, 2025; 17(5): 106384
Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.106384

Effectiveness of early enteral nutrition support in patients undergoing gastrointestinal perforation repair surgery within the enhanced recovery

Miao-Miao Hu, Ya-Li Ding, Juan Li

Miao-Miao Hu, Juan Li, Intensive Care Unit, Suzhou Hospital of Anhui Medical University, Suzhou Municipal Hospital of Anhui Province, Suzhou 234000, Anhui Province, China

Ya-Li Ding, Department of General Surgery, Suzhou Hospital of Anhui Medical University, Suzhou Municipal Hospital of Anhui Province, Suzhou 234000, Anhui Province, China

Co-first authors: Miao-Miao Hu and Ya-Li Ding.

Author contributions: Hu MM designed and coordinated the study and wrote the manuscript; Ding YL performed the experiments, acquired, and analyzed the data; Li J interpreted the data; All authors approved the final version of the article. Hu MM and Ding YL contributed equally to this study as co-first authors.

Institutional review board statement: The study was reviewed and approved by the Suzhou Municipal Hospital of Anhui Province Institutional Review Board.

Informed consent statement: All study participants provided informed written consent before study enrollment.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Miao-Miao Hu, Associate Chief Nurse, Intensive Care Unit, Suzhou Hospital of Anhui Medical University, Suzhou Municipal Hospital of Anhui Province, No. 299 Bianhe Middle Road, Suzhou 234000, Anhui Province, China. 15505579783@163.com

Received: February 26, 2025
Revised: March 17, 2025
Accepted: March 27, 2025
Published online: May 27, 2025
Processing time: 85 Days and 19.1 Hours

Core Tip

Core Tip: This retrospective study compared early enteral nutrition (Enhanced Recovery After Surgery [ERAS] protocol) with traditional parenteral nutrition in 66 patients undergoing gastrointestinal perforation repair. The observation group (n = 34) showed shorter times to first flatus and bowel movement, higher nutritional (prealbumin, albumin, hemoglobin) and immune markers (immunoglobulin A [IgA], IgM, IgG), and lower C-reactive protein levels on postoperative day 5 vs the control group (n = 32). Adverse reactions were lower in the observation group (8.82% vs 28.13%). Early enteral nutrition under ERAS improves recovery, nutritional status, immune function, and reduces inflammation with better safety.