Qu ZJ, Wang YN, Liu YH, Duan RH. Association between hematological disorders and gallbladder stones: A review of current evidence. World J Gastrointest Surg 2025; 17(5): 105058 [DOI: 10.4240/wjgs.v17.i5.105058]
Corresponding Author of This Article
Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Jie Qu, Department of Nephrology, Second Hospital of Jilin University, Changchun 130022, Jilin Province, China
Yu-Ning Wang, Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun 130022, Jilin Province, China
Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Rui-Heng Duan, Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130022, Jilin Province, China
Co-corresponding authors: Ya-Hui Liu and Rui-Heng Duan.
Author contributions: Qu ZJ wrote the initial draft; Wang YN contributed to the study design and literature review; Liu YH contributed to the study design; Duan RH helped design the study and contributed to revisions to the final manuscript. Liu YH and Duan RH are co-corresponding authors and contributed equally to this work in terms of conceptual design, critical revision, and final approval of the manuscript. Liu YH will serve as the primary corresponding author responsible for all communications with the journal during the submission, peer review, and publication process, as well as for coordinating administrative requirements such as conflict-of-interest documentation. All authors approved the final version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Received: January 10, 2025 Revised: March 12, 2025 Accepted: April 16, 2025 Published online: May 27, 2025 Processing time: 133 Days and 12.2 Hours
Core Tip
Core Tip: Hematological disorders, particularly those involving chronic hemolysis, significantly increase the risk of gallbladder stone formation. The excess bilirubin produced during hemolysis can precipitate as pigment stones, with genetic factors further influencing this process. Patients with conditions such as sickle cell disease and thalassemia are at higher risk due to both hemolysis and genetic mutations that affect bilirubin metabolism. Management of gallstones in these patients requires careful diagnostic and therapeutic strategies, including regular screening, surgical interventions, and consideration of underlying conditions. Further research into genetic, biochemical, and environmental factors will aid in improving prevention and treatment approaches.
