©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. May 27, 2025; 17(5): 104235
Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.104235
Published online May 27, 2025. doi: 10.4240/wjgs.v17.i5.104235
Integrating clinical and molecular approaches to improve survival in esophageal squamous cell carcinoma
Qian-Cheng Du, Hui Nian, Department of Thoracic Surgery, Shanghai Xuhui Central Hospital, Shanghai 200031, China
Yu Bai, Intensive Care Unit, Shanghai Xuhui Central Hospital, Shanghai 200031, China
Author contributions: Du QC and Bai Y contributed to the analysis and manuscript writing, they contributed equally as co-first authors; Nian H conceptualized and supervised the article’s development; and all authors have read and endorsed the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Hui Nian, Department of Thoracic Surgery, Shanghai Xuhui Central Hospital, No. 366 Longchuan North Road, Xuhui District, Shanghai 200031, China.
Received: December 16, 2024
Revised: March 16, 2025
Accepted: April 10, 2025
Published online: May 27, 2025
Processing time: 160 Days and 18.7 Hours
Revised: March 16, 2025
Accepted: April 10, 2025
Published online: May 27, 2025
Processing time: 160 Days and 18.7 Hours
Core Tip
Core Tip: This study underscores the key prognostic factors affecting long-term survival in esophageal squamous cell carcinoma, with a particular focus on tumor stage, age, gender, and treatment modality. The findings highlight the importance of integrating molecular biomarkers and psychosocial factors into survival models to improve prediction accuracy. Future research should focus on prospective studies and developing personalized treatment strategies that incorporate both traditional and modern therapeutic approaches to improve patient outcomes.