Liu SG, Xu XJ, He M, Zhao JD, Pei L. Perioperative risk factors for prognosis in patients undergoing radical esophagectomy: A retrospective study. World J Gastrointest Surg 2025; 17(4): 103483 [DOI: 10.4240/wjgs.v17.i4.103483]
Corresponding Author of This Article
Lin Pei, Professor, Hebei Key Lab Turbid, Hebei Academy of Chinese Medical Sciences, No. 209 Jianhua South Street, Shijiazhuang 050000, Hebei Province, China. peilin3368@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2025; 17(4): 103483 Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.103483
Perioperative risk factors for prognosis in patients undergoing radical esophagectomy: A retrospective study
Shu-Gang Liu, Xin-Jian Xu, Ming He, Ji-Dong Zhao, Lin Pei
Shu-Gang Liu, Department of Traditional Chinese Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Xin-Jian Xu, Ming He, Ji-Dong Zhao, Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Lin Pei, Hebei Key Lab Turbid, Hebei Academy of Chinese Medical Sciences, Shijiazhuang 050000, Hebei Province, China
Co-first authors: Shu-Gang Liu and Xin-Jian Xu.
Author contributions: Xu XJ and Liu SG contributed equally to the study design, data collection, and manuscript drafting, they contributed equally to this article, they are the co-first authors of this manuscript; He M and Zhao JD participated in surgical procedures, data analysis, and clinical interpretation; Pei L supervised the study, revised the manuscript, and oversaw submission; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Fourth Hospital of Hebei Medical University, approval No. K2021-Approval-039 (5. 25).
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Pei, Professor, Hebei Key Lab Turbid, Hebei Academy of Chinese Medical Sciences, No. 209 Jianhua South Street, Shijiazhuang 050000, Hebei Province, China. peilin3368@sina.com
Received: December 5, 2024 Revised: February 6, 2025 Accepted: February 26, 2025 Published online: April 27, 2025 Processing time: 113 Days and 21.8 Hours
Core Tip
Core Tip: In this retrospective analysis of 378 patients who underwent radical esophagectomy for esophageal cancer, we identified tumor-node-metastasis staging, tumor differentiation, and extended postoperative analgesic use (> 5 days) as independent predictors of overall survival. Of particular significance was the adverse impact of prolonged administration of both opioids and nonsteroidal anti-inflammatory drugs on survival outcomes. These findings emphasize the critical importance of precise perioperative management, specifically regarding optimal pain control protocols, in enhancing patient outcomes. Further validation through multicenter, prospective studies and investigation of underlying mechanisms is warranted to optimize perioperative care strategies and improve long-term survival rates in this patient population.
