Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2025; 17(3): 102638
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.102638
Predictive value of serum calcium ion level in patients with colorectal cancer: A retrospective cohort study
Yin Shu, Ke-Jin Li, Subinur Sulayman, Zi-Yi Zhang, Saibihutula Ababaike, Kuan Wang, Xiang-Yue Zeng, Yi Chen, Ze-Liang Zhao
Yin Shu, Ke-Jin Li, Subinur Sulayman, Zi-Yi Zhang, Saibihutula Ababaike, Kuan Wang, Xiang-Yue Zeng, Yi Chen, Ze-Liang Zhao, Department of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Co-first authors: Yin Shu and Ke-Jin Li.
Author contributions: Shu Y was responsible for the study design, data acquisition, and preliminary analysis, and also took the lead in drafting the initial manuscript; Li KJ made significant contributions to the data analysis and interpretation, and played a key role in revising and improving the manuscript; Shu Y and Li KJ designed the article format, collected the data, and wrote the manuscript; Sulayman S, Zhang ZY, Ababaike S, Wang K, Zeng XY, and Chen Y were responsible for the statistical analyses; Zhao ZL designed the main study and critically revised the manuscript; All authors read and approved the final manuscript. Both authors made equal contributions to the study and as co-first authors of this manuscript.
Institutional review board statement: The Ethics Committee of Affiliated Cancer Hospital of Xinjiang Medical University approved the ethical review after reviewing that the study complied with ethical principles (No. G-2015021).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at zlzhao71@163.com. Participants gave informed consent for data sharing.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ze-Liang Zhao, MD, PhD, Professor, Department of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical University, No. 789 Suzhou East Street, Xinshi District, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. zlzhao71@163.com
Received: October 24, 2024
Revised: December 18, 2024
Accepted: January 20, 2025
Published online: March 27, 2025
Processing time: 123 Days and 8.6 Hours
Core Tip

Core Tip: Serum calcium ion (Ca2+) is a readily available and cost-effective marker used in routine screenings but has not been studied in relation to digestive tract malignancies until now. This study examined the association of serum Ca2+ concentrations with clinical indicators in patients with colorectal cancer (CRC) undergoing radical surgery. The results show that reduced serum Ca2+ concentrations on the first day after surgery are associated with poorer overall survival and progression-free survival in patients with CRC.