High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis

doi:10.4240/wjgs.v17.i3.101940

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Mar 27, 2025 (publication date) through Feb 24, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. Mar 27, 2025; 17(3): 101940
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.101940

High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis

Dong Woo Shin, Yoon Ah Cho, Sung-Hoon Moon, Tae Hyung Kim, Ji-Won Park, Jung-Woo Lee, Ji-Young Choe, Min-Jeong Kim, Sung-Eun Kim

Dong Woo Shin, Sung-Hoon Moon, Tae Hyung Kim, Ji-Won Park, Sung-Eun Kim, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Gyeonggi-do, South Korea

Yoon Ah Cho, Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea

Jung-Woo Lee, Department of Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, South Korea

Ji-Young Choe, Anatomic Pathology Reference Lab, Seegene Medical Foundation, Seoul 04805, South Korea

Min-Jeong Kim, Department of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, South Korea

Co-first authors: Dong Woo Shin and Yoon Ah Cho.

Author contributions: Shin DW and Cho YA contributed equally to this manuscript as co-first authors. Shin DW and Kim SE contributed to the conceptualization and methodology, and writing-review and editing of this manuscript; Choe JY participated in the data collection; Cho YA took part in the construction of tissue microarray of this study, interpretation of the data and contributed to writing and revising the manuscript; Park JW and Kim MJ contributed to the data acquisition and analysis; Shin DW and Lee JW contributed to the data analysis and visualization; Shin DW and Moon SH contributed to the software and writing-original draft; Kim SE contributed to the supervision. All authors approved the final version of the manuscript before submission.

Supported by National Research Foundation of Korea Grant Funded by the Korea Government, No. RS-2023-00213951.

Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of Hallym University Sacred Heart Hospital (No. HALLYM IRB 2022-03-012-001).

Informed consent statement: Given the study’s retrospective design using anonymized clinical data, the requirement for informed consent was waived by the Institutional Review Board of Hallym University Sacred Heart Hospital.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Sung-Eun Kim, MD, PhD, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, No. 22 Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang 14068, Gyeonggi-do, South Korea. sekim@hallym.or.kr

Received: October 2, 2024
Revised: November 25, 2024
Accepted: January 6, 2025
Published online: March 27, 2025
Processing time: 144 Days and 21.5 Hours

Core Tip

Core Tip: High cellular prion protein (PrP^C) expression is significantly associated with early recurrence and decreased survival period in cholangiocarcinoma patients following surgical resection. PrPC expression serves as an independent prognostic factor for overall survival and recurrence-free survival. These findings suggest that PrPC could be a valuable prognostic biomarker following curative surgery.