Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2025; 17(2): 101365
Published online Feb 27, 2025. doi: 10.4240/wjgs.v17.i2.101365
Long-term survival outcomes of duodenal adenocarcinoma: A cohort study with 15-year single-center experience
Qing-Feng Xie, Lian-Sheng Long, Yang-Yang Luo, Meng-Ting Lu, Wai-Kit Ming, Li-Ying Zhao, Hao Liu
Qing-Feng Xie, Lian-Sheng Long, Yang-Yang Luo, Meng-Ting Lu, Li-Ying Zhao, Hao Liu, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Lian-Sheng Long, Department of General Surgery, General Hospital of Southern Theater Command, Guangzhou 510515, Guangdong Province, China
Wai-Kit Ming, Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong 999077, China
Co-first authors: Qing-Feng Xie and Lian-Sheng Long.
Co-corresponding authors: Wai-Kit Ming and Hao Liu.
Author contributions: Xie QF and Long LS contribute equally to this study as co-first authors; Ming WK and Liu H contribute equally to this study as co-corresponding authors; all authors were involved in concept and design; Xie QF, Chen T, Luo YY were involved in data acquisition, analysis or interpretation; Xie QF, Chen T, Luo YY, Lu MT were involved in drafting of the manuscript; Liu H, Zhao LY, Ming WK were involved in modification of important knowledge content of manuscript; Xie QF and Liu H were involved in statistical analysis; Ming WK was involved in administrative, technical or material support.
Supported by Natural Science Foundation of Guangdong Province of China, No. 2023A1515010785; Key Clinical Technique of Guangzhou, No. 2023P-ZD01; and Clinical Research Program of Nanfang Hospital, Southern Medical University, No. 2021CR003.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki and was approved by the ethical committee of the related institution (NFEC-2024-171).
Informed consent statement: We have obtained informed consent from patients for this clinical study.
Conflict-of-interest statement: All the authors declare no conflicts of interest, financial or otherwise.
Data sharing statement: Data were obtained from duodenal cancer database of Nanfang Hospital, Guangzhou, China, so data sharing does not apply to this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hao Liu, MD, PhD, Associate Professor, Department of General Surgery, Nanfang Hospital, Southern Medical University, North No. 1838 Guangzhou Ave., Guangzhou 510515, Guangdong Province, China. liuhaofbi@163.com
Received: September 12, 2024
Revised: October 25, 2024
Accepted: November 25, 2024
Published online: February 27, 2025
Processing time: 132 Days and 5.6 Hours
Core Tip

Core Tip: Numerous meta-analyses and systematic reviews have delved into the treatment of duodenal adenocarcinoma (DA), yet the majority of the studies retrospective, single-center, and small sample size series, particularly in China. To bridge this knowledge gap, we conducted a hospital-based cohort study in our 15-year experience with DA aimed at investigating the long-term outcomes of the patients with DA, along with analyzing the impact of the tumor characteristics, operations and adjuvant therapy on survival outcomes.