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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2025; 17(10): 110017
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110017
Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.110017
Complete prevention of anastomotic leakage using total enteric flow diversion
Tao Hu, Jing Wang, Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Tao Hu, Department of Anesthesiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410011, Hunan Province, China
Nan-Hui Yu, Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Co-first authors: Tao Hu and Jing Wang.
Author contributions: Hu T carried out sample collection, analysis, and data entry; Hu T and Wang J conducted animal anesthesia and other auxiliary procedures; Wang J and Yu NH drafted the main text, created the figures, and prepared the manuscript; Yu NH designed the study, prepared the research protocol, and performed the surgical operations. Hu T and Wang J contributed equally to this manuscript and are co-first authors. All the authors have read and approved the final manuscript.
Supported by the Fundamental Research Funds for the Central Universities of Central South University, No. 2024XQLH027.
Institutional animal care and use committee statement: All animal experiments were performed in compliance with the internationally accepted principles for the care and use of laboratory animals. The study was approved by the Institutional Animal Care and Use Committee of the Second Xiangya Hospital, Central South University [Laboratory Animal Use License No. SYXK (Xiang) 2021-0012; Approval No. 2021934].
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nan-Hui Yu, PhD, Research Fellow, Department of Gastrointestinal Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. yunanhui@csu.edu.cn
Received: May 28, 2025
Revised: July 2, 2025
Accepted: August 13, 2025
Published online: October 27, 2025
Processing time: 149 Days and 10.6 Hours
Revised: July 2, 2025
Accepted: August 13, 2025
Published online: October 27, 2025
Processing time: 149 Days and 10.6 Hours
Core Tip
Core Tip: This study evaluated a novel total enteric flow diversion technique using a modified ileostomy tube with balloon inflated to 20 kPa in a pig model of colonic anastomotic leakage (AL). Compared with the control group, the diversion group showed complete prevention of AL, no peritonitis or abscesses, and mild mucosal injury without necrosis. This technique may offer an effective alternative to traditional stomas for AL prevention.