Bi B, Liu C, Chai J, Duan YM. Retrospective analysis of predictive factors for pathological complete response after neoadjuvant chemotherapy in gastric cancer. World J Gastrointest Surg 2025; 17(10): 109700 [DOI: 10.4240/wjgs.v17.i10.109700]
Corresponding Author of This Article
Yun-Ming Duan, PhD, School of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, No. 619 Changcheng Road, Tai’an 271000, Shandong Province, China. dymin2019@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 27, 2025 (publication date) through Oct 24, 2025
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Publication Name
World Journal of Gastrointestinal Surgery
ISSN
1948-9366
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Bi B, Liu C, Chai J, Duan YM. Retrospective analysis of predictive factors for pathological complete response after neoadjuvant chemotherapy in gastric cancer. World J Gastrointest Surg 2025; 17(10): 109700 [DOI: 10.4240/wjgs.v17.i10.109700]
World J Gastrointest Surg. Oct 27, 2025; 17(10): 109700 Published online Oct 27, 2025. doi: 10.4240/wjgs.v17.i10.109700
Retrospective analysis of predictive factors for pathological complete response after neoadjuvant chemotherapy in gastric cancer
Bo Bi, Chen Liu, Jie Chai, Yun-Ming Duan
Bo Bi, Jie Chai, Department of Gastroenterological Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
Chen Liu, Comprehensive Ward, Tai’an Central Hospital Gaoxin Hospital District Comprehensive Ward (Healthcare Ward), Tai’an 271000, Shandong Province, China
Yun-Ming Duan, School of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an 271000, Shandong Province, China
Author contributions: Bi B conceived the study, collected and analyzed data, and drafted the manuscript; Liu C and Chai J contributed to data collection, statistical analysis, and manuscript revision; Duan YM supervised the study, provided critical revision, and approved the final manuscript; and all authors read and approved the final version.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Shandong Cancer Hospital and Institute, Shandong First Medical University, approval No. SDTHEC2024003103.
Informed consent statement: Informed consent was waived due to the retrospective design and the use of anonymized data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Ming Duan, PhD, School of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, No. 619 Changcheng Road, Tai’an 271000, Shandong Province, China. dymin2019@163.com
Received: June 24, 2025 Revised: July 30, 2025 Accepted: August 21, 2025 Published online: October 27, 2025 Processing time: 121 Days and 17.6 Hours
Core Tip
Core Tip: This study included patients with pathologically confirmed gastric adenocarcinoma who received neoadjuvant chemotherapy and completed radical gastrectomy + D2 dissection. Unified tumor regression grade assessment defines pathological complete response as the absence of residual primary tumor and lymph node metastasis. The system collected demographic data, comorbidities, tumor location and clinical stage, Lauren classification, human epidermal growth factor receptor 2/microsatellite instability/programmed death-ligand 1, baseline and dynamic laboratory indicators imaging and endoscopic responses, chemotherapy regimens/cycles/dose intensities and adverse reactions. With pathological complete responses the primary outcome, univariate and multivariate logistic regression were used to screen independent predictors.
