Clinical application value of long non-coding RNAs signatures of genomic instability in predicting prognosis of hepatocellular carcinoma

doi:10.4240/wjgs.v16.i8.2386

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Aug 27, 2024; 16(8): 2386-2392
Published online Aug 27, 2024. doi: 10.4240/wjgs.v16.i8.2386

Clinical application value of long non-coding RNAs signatures of genomic instability in predicting prognosis of hepatocellular carcinoma

Xiao-Wen Xing, Xiao Huang, Wei-Peng Li, Ming-Ke Wang, Ji-Shun Yang

Xiao-Wen Xing, Xiao Huang, Wei-Peng Li, Ming-Ke Wang, Department of Disease Control and Prevention, Naval Medical Center, Naval Medical University, Shanghai 200052, China

Ji-Shun Yang, Medical Care Center, Naval Medical University, Shanghai 200052, China

Co-corresponding authors: Ming-Ke Wang and Ji-Shun Yang.

Author contributions: Wang MK and Yang JS conceptualized, designed, and revised the manuscript; Xing XW wrote the draft; Huang X and Li WP collected the literature. All authors have read and approved the final manuscript. Both Wang MK and Yang JS conceptualized, proposed, designed, and supervised the whole process of the article, and played important and indispensable roles in the manuscript preparation and revision as the co-corresponding authors.

Supported by The National Key R&D Program of China (Key Special Project for Marine Environmental Security and Sustainable Development of Coral Reefs 2022-3.3), No. 2022YFC3103-004001; and Scientific Research Foundation of Shanghai Municipal Health Commission of Changning District, No. 20234Y038.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ming-Ke Wang, MD, PhD, Associate Chief Physician, Department of Disease Control and Prevention, Naval Medical Center, Naval Medical University, No. 338 Huaihai West Road, Changning District, Shanghai 200052, China. wmke021@163.com

Received: March 19, 2024
Revised: May 16, 2024
Accepted: June 5, 2024
Published online: August 27, 2024
Processing time: 150 Days and 2.2 Hours

Core Tip

Core Tip: Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer-related mortality globally, is characterized by high rates of recurrence and metastasis. Long non-coding RNAs related to genomic instability emerge as promising biomarkers for HCC prognosis. Here, we discuss their clinical significance as prognostic models and offer insights into ongoing efforts to develop diverse models, with an aim to enhance the scope of research on HCC prognosis and diagnosis.