Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2024; 16(11): 3437-3444
Published online Nov 27, 2024. doi: 10.4240/wjgs.v16.i11.3437
Risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding
Fei Zou, Mian-Tao Wu, Yong-Yi Wang
Fei Zou, Department of Oncology, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College/Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, Chongqing 400060, China
Mian-Tao Wu, Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Yong-Yi Wang, Department of Occupational Disease and Poisoning, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College/Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, Chongqing 400060, China
Co-first authors: Fei Zou and Mian-Tao Wu.
Author contributions: Wang YY proposed the concept of this study; Zou F was responsible for the literature review, methodology, data acquisition, and manuscript writing; Wu MT handled data analysis and manuscript review; All authors have read and approved the final manuscript.
Supported by The First Batch of Key Discipline on Public Health in Chongqing.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College.
Informed consent statement: Due to the study's retrospective nature, the necessity to procure informed consent was exempted.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analysed during the current study available from the corresponding author on reasonable request at zybk2023@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong-Yi Wang, Doctor, Chief Physician, Department of Occupational Disease and Poisoning, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College/Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, No. 301 Nancheng Avenue, Nanan District, Chongqing 400060, China. zybk2023@163.com
Received: March 10, 2024
Revised: August 19, 2024
Accepted: August 23, 2024
Published online: November 27, 2024
Processing time: 234 Days and 11.7 Hours
Core Tip

Core Tip: In order to identify risk factors for hemocoagulase-associated hypofibrinogenemia, a retrospective study analyzing data from 109 patients with gastrointestinal bleeding was conducted. We found that higher doses of total hemocoagulase, female gender, and a lower baseline fibrinogen level were risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding.