Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2023; 15(9): 1919-1931
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.1919
Autologous bone marrow infusion via portal vein combined with splenectomy for decompensated liver cirrhosis: A retrospective study
Bao-Chi Liu, Ming-Rong Cheng, Lin Lang, Lei Li, Yan-Hui Si, Ai-Jun Li, Qing Xu, Hui Zhang
Bao-Chi Liu, Lei Li, Yan-Hui Si, Department of Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Bao-Chi Liu, Lin Lang, He Nuo Medical Clinic, Shanghai New Hongqiao International Medical Center, Shanghai 201100, China
Ming-Rong Cheng, Department of Anorectal Surgery, The Third Affiliated Hospital of Guizhou Medical University, Duyun 558000, Guizhou Province, China
Ai-Jun Li, Department of Hepatobiliary Surgery, Oriental Hepatobiliary Surgery Hospital, Shanghai 200433, China
Qing Xu, Department of Hepatobiliary Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Hui Zhang, Department of Hepatobiliary Surgery, Shanghai Oriental Hospital Affiliated to Tongji University, Shanghai 200120, China
Author contributions: Liu BC outlined the content and reviewed the manuscript; Cheng MR reviewed the literature and wrote the manuscript; Lang L, Li L and Si YH performed this experimental work and analyzed the data; Li AJ, Xu Q and Zhang H participated in the experiments; Liu BC and Cheng MR contributed equally as joint first authors.
Supported by Shenkang Hospital Development Center of Shanghai, China, No. SHDC12016129.
Institutional review board statement: This study was approved by the Ethics Committee of the Shanghai Public Health Clinical Center (2013-030).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Chi Liu, Doctor, MD, Chief Physician, Department of Surgery, Shanghai Public Health Clinical Center, Fudan University, No. 2901 Caolang Road, Jinshan District, Shanghai 201508, China. liubaochi200227@aliyun.com
Received: April 6, 2023
Peer-review started: April 6, 2023
First decision: May 30, 2023
Revised: June 8, 2023
Accepted: July 11, 2023
Article in press: July 11, 2023
Published online: September 27, 2023
Processing time: 169 Days and 7.3 Hours
Core Tip

Core Tip: In this study, autologous bone marrow infusion (ABMI) through the portal vein in patients with decompensated liver cirrhosis (DLC) can significantly improve liver synthetic and secretory functions and is effective in patients with DLC. And it is the first attempt to investigate the impact of splenectomy on bone marrow hematopoietic function and cellular immune function after ABMI in patients with DLC.