Statistical proof of Helicobacter pylori eradication in preventing metachronous gastric cancer after endoscopic resection in an East Asian population

Core Tip

Core Tip: Gastrointestinal infections caused by Helicobacter pylori (H. pylori) is one of the most well-known infections in the human digestive tract. This bacterium successfully has been colonized in the stomach of more than 4 billion people worldwide. In many developing countries, these microorganisms are colonized in childhood, which in later years may develop to severe complications, particularly gastric adenocarcinoma. In the present study, we statistically evaluated the effectiveness of H. pylori eradication in reducing the risk of tend to metachronous gastric cancer (MGC) in Asian populations. Our results suggested that the eradication of this pathogen significantly reduced the risk of susceptibility to MGC in these patients. However, based on the available evidence, several factors such as increasing age, severe atrophy in the corpus and antrum, and intestinal metaplasia all may increase the risk of MGC in H. pylori extirpated patients. Unfortunately, there is no detailed information about the location of the stomach where the reduction of gastric cancer can be achieved after H. pylori eradication. Therefore, in future studies, more research should be done on the recent puzzle.