Zhao Y, Liu Y, Zhou L, Du GS, He Q. Trends of rapamycin in survival benefits of liver transplantation for hepatocellular carcinoma. World J Gastrointest Surg 2021; 13(9): 953-966 [PMID: 34621472 DOI: 10.4240/wjgs.v13.i9.953]
Corresponding Author of This Article
Guo-Sheng Du, MD, Professor, Department of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. duguosheng309@126.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2021; 13(9): 953-966 Published online Sep 27, 2021. doi: 10.4240/wjgs.v13.i9.953
Trends of rapamycin in survival benefits of liver transplantation for hepatocellular carcinoma
Yang Zhao, Yu Liu, Lin Zhou, Guo-Sheng Du, Qiang He
Yang Zhao, Yu Liu, Lin Zhou, Qiang He, Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Guo-Sheng Du, Department of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Zhao Y performed the review of the literature and wrote the original draft; Liu Y, Zhou L, He Q, and Du GS reviewed and edited the manuscript; all authors read, revised, and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Sheng Du, MD, Professor, Department of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. duguosheng309@126.com
Received: February 21, 2021 Peer-review started: February 21, 2021 First decision: May 8, 2021 Revised: May 17, 2021 Accepted: July 26, 2021 Article in press: July 26, 2021 Published online: September 27, 2021 Processing time: 209 Days and 7.6 Hours
Core Tip
Core Tip: Although liver transplantation (LT) is the radical method for patients with hepatocellular carcinoma (HCC), especially advanced HCC, by improving the survival benefits, the postoperative tumor recurrence seriously affects the survival of the graft and patients. The rapamycin (RAPA)-based immunosuppressive regimen has been recommended as a priority after LT due to its favorable survival benefits. In this paper, we describe the immune regulation and anti-tumor mechanism of RAPA, summarize the progress of RAPA transformation therapy after LT for HCC, further analyze the survival benefits of combined anticancer drugs and targeted drugs, and comb the prospect of immune checkpoint therapy such as programmed cell death protein 1, in order to provide a theoretical basis for RAPA transformation therapy after LT for HCC.
