Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2021; 13(9): 1000-1011
Published online Sep 27, 2021. doi: 10.4240/wjgs.v13.i9.1000
Evaluating the benefit of adjuvant chemotherapy in patients with ypT0–1 rectal cancer treated with preoperative chemoradiotherapy
Ye Won Jeon, In Ja Park, Jeong Eun Kim, Jin-Hong Park, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim
Ye Won Jeon, Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul 05505, South Korea
In Ja Park, Seok-Byung Lim, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Chang Sik Yu, Jin Cheon Kim, Department of Colon and Rectal Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul 05505, South Korea
Jeong Eun Kim, Department of Oncology, Asan Medical Center and University of Ulsan College of Medicine, Seoul 05505, South Korea
Jin-Hong Park, Department of Radiation Oncology, Asan Medical Center and University of Ulsan College of Medicine, Seoul 05505, South Korea
Author contributions: Jeon YW and Park IJ conceptualized and designed the study and wrote the manuscript; Jeon YW provided data analysis and literature review; Kim JE and Park JH provided clinical data and critical revision; Lim SB, Lee JL, Yoon YS, Kim CW, Yu CS, and Kim JC critical revision and editing, and all authors approved of the final version.
Institutional review board statement: This study was approved by the Institutional Review Board of the Asan Medical Center, No. 2017-1114.
Informed consent statement: The requirement for obtaining an informed consent was waived.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Data are available upon reasonable request. We may be able to share de-identified participant data with researchers following the publication of this manuscript. Requests for data should be directed to the corresponding author. Data sharing will need to be approved by third-party data providers.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: In Ja Park, MD, PhD, Doctor, Professor, Surgeon, Department of Colon and Rectal Surgery, Asan Medical Center and University of Ulsan College of Medicine, No. 88 Olympic-ro, Songpa-gu, Seoul 05505, South Korea. ipark@amc.seoul.kr
Received: February 21, 2021
Peer-review started: February 21, 2021
First decision: May 13, 2021
Revised: May 22, 2021
Accepted: August 2, 2021
Article in press: August 2, 2021
Published online: September 27, 2021
Processing time: 209 Days and 9 Hours
Core Tip

Core Tip: Adjuvant chemotherapy (ACTx) is administered based on the clinical stage of rectal cancer after preoperative chemoradiotherapy (PCRT), regardless of post-treatment pathologic stage. Prognosis differs according to post-treatment pathologic stage or regression grade. Adjuvant treatment may be administered based on prognostic influence. Patients with ypT0-1 rectal cancer with favorable oncologic outcomes were included. Since local excision (LE) frequency has increased, ACTx effects in these patients need to be studied. We included patients who underwent LE. ACTx in patients with ypT0-1 rectal cancer after PCRT and LE did not exert benefits in terms of overall survival and recurrence-free survival.