Observational Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2020; 12(9): 390-396
Published online Sep 27, 2020. doi: 10.4240/wjgs.v12.i9.390
Predictive significance of cancer related-inflammatory markers in locally advanced rectal cancer
Kitinat Timudom, Thawatchai Akaraviputh, Vitoon Chinswangwatanakul, Ananya Pongpaibul, Pornpim Korpraphong, Janjira Petsuksiri, Suthinee Ithimakin, Atthaphorn Trakarnsanga
Kitinat Timudom, Thawatchai Akaraviputh, Vitoon Chinswangwatanakul, Atthaphorn Trakarnsanga, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Ananya Pongpaibul, Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Pornpim Korpraphong, Janjira Petsuksiri, Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Suthinee Ithimakin, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Author contributions: Trakarnsanga A was involved in the conceptualization, project administration, writing review and editing; Timudom K was involved in data curation, and writing the original draft; Akaraviputh T, Pongpaibul A, Korpraphong P, Petsuksiri J, Ithimakin S and Chinswangwatanakul V were involved in writing review and editing; all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by Siriraj’s institutional review board committee and the committee’s reference number is 335/2561(EC4).
Informed consent statement: All patient information is de-identified.
Conflict-of-interest statement: The authors declare that they have no competing interests
Data sharing statement: The dataset utilized during the current study is available within the institutional collected data system which was used under Siriraj’s institutional review board committee approval for this study. Data are available upon reasonable request with permission of Siriraj’s institutional review board committee.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Atthaphorn Trakarnsanga, MD, Associated Professor, Department of Surgery, Faculty of Medicine, Siriraj Hospital, 2 Prannok, Bangkoknoi, Bangkok 10700, Thailand. atthaphorn.tra@mahidol.ac.th
Received: February 27, 2020
Peer-review started: February 27, 2020
First decision: April 22, 2020
Revised: May 11, 2020
Accepted: August 16, 2020
Article in press: August 16, 2020
Published online: September 27, 2020
Processing time: 211 Days and 7.7 Hours
Core Tip

Core Tip: Previously, correlations between markers representing cancer-related inflammation, including high neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) and unfavorable oncological outcomes have been reported. The present study demonstrated the predictive role of these markers in patients with locally advanced rectal cancer. Pretreatment NLR, MLR, and PLR were higher in those with advanced pathological stage and high neoadjuvant rectal score, and represented a poor outcome.