You L, Yao L, Mao YS, Zou CF, Jin C, Fu DL. Partial pancreatic tail preserving subtotal pancreatectomy for pancreatic cancer: Improving glycemic control and quality of life without compromising oncological outcomes. World J Gastrointest Surg 2020; 12(12): 491-506 [PMID: 33437401 DOI: 10.4240/wjgs.v12.i12.491]
Corresponding Author of This Article
De-Liang Fu, MD, PhD, Chairman, Professor, Surgeon, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, No. 12 Central Urumqi Road, Shanghai 200040, China. surgeonfu@163.com
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Dec 27, 2020; 12(12): 491-506 Published online Dec 27, 2020. doi: 10.4240/wjgs.v12.i12.491
Partial pancreatic tail preserving subtotal pancreatectomy for pancreatic cancer: Improving glycemic control and quality of life without compromising oncological outcomes
Li You, Lie Yao, Yi-Shen Mao, Cai-Feng Zou, Chen Jin, De-Liang Fu
Li You, Lie Yao, Yi-Shen Mao, Cai-Feng Zou, Department of Pancreatic Surgery, Huashan Hospital, Shanghai 200040, China
Chen Jin, Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China
De-Liang Fu, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai 200040, China
Author contributions: You L and Fu DL designed the study; You L wrote the manuscript; You L, Yao L, Mao YS, and Zou CF collected the data and performed the statistical analysis; Yao L, Jin C, and Fu DL prepared the final version of the manuscript and designed the tables and figures; Yao L helped draft the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Huashan Hospital Affiliated to Fudan University (Approval No. KY 2019-566).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no conflicts of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: De-Liang Fu, MD, PhD, Chairman, Professor, Surgeon, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, No. 12 Central Urumqi Road, Shanghai 200040, China. surgeonfu@163.com
Received: June 30, 2020 Peer-review started: June 30, 2020 First decision: September 18, 2020 Revised: September 30, 2020 Accepted: November 11, 2020 Article in press: November 11, 2020 Published online: December 27, 2020 Processing time: 174 Days and 6.3 Hours
Core Tip
Core Tip: In order to improve postoperative glycemic control and quality of life (QoL) while ensuring safety and oncological efficacy, we performed partial pancreatic tail preserving subtotal pancreatectomy (PPTP-SP) as an alternative to total pancreatectomy in selected patients. No patients in the PPTP-SP group developed cancer recurrence in the pancreatic tail stump or splenic hilum, or a clinical pancreatic fistula. Although the exocrine function of the remnant pancreas almost completely degenerated, its endocrine function was preserved. Our long-term follow-up indicated that PPTP-SP achieved significantly better postoperative glycemic control and QoL without compromising oncological outcomes. Moreover, PPTP-SP could also be indicated for other pancreatic neoplasms.
