Tai YS, Jou IM, Jung YC, Wu CL, Shiau AL, Chen CY. In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats. World J Gastrointest Surg 2019; 11(2): 85-92 [PMID: 30842814 DOI: 10.4240/wjgs.v11.i2.85]
Corresponding Author of This Article
Chih-Yi Chen, MD, PhD, Doctor, Professor, Institute of Medicine, Department of Surgery, Chung Shan Medical University Hospital, No.110, Sec.1, Jianguo N. Rd, Taichung 402, Taiwan. cshy1566@csh.org.tw
Research Domain of This Article
Surgery
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Tai YS, Jou IM, Jung YC, Wu CL, Shiau AL, Chen CY. In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats. World J Gastrointest Surg 2019; 11(2): 85-92 [PMID: 30842814 DOI: 10.4240/wjgs.v11.i2.85]
Yun-Sheng Tai, Chih-Yi Chen, Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Yun-Sheng Tai, Department of Surgery, EDa Hospital, Kaohsiung 824, Taiwan
Yun-Sheng Tai, I-Shou University College of Medicine, Kaohsiung 824, Taiwan
I-Ming Jou, Department of Orthopedics, EDa Hospital, Kaohsiung 824, Taiwan
Yun-Chih Jung, Department of Pathology, Sinlau Christian Hospital, Tainan 701, Taiwan
Chao-Liang Wu, Department of Biochemistry, National Cheng Kung University Medical College, Tainan 701, Taiwan
Ai-Li Shiau, Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan 701, Taiwan
Author contributions: Tai YS designed and performed the experiments; Jou IM, Wu CL and Shiau AL analyzed the data; Tai YS and Chen CY wrote the paper.
Institutional review board statement: Not applicable to this study.
Institutional animal care and use committee statement: This study protocol was reviewed and approved by the Affidavit of Approval of Animal Use Protocol National Cheng Kung University.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Chih-Yi Chen, MD, PhD, Doctor, Professor, Institute of Medicine, Department of Surgery, Chung Shan Medical University Hospital, No.110, Sec.1, Jianguo N. Rd, Taichung 402, Taiwan. cshy1566@csh.org.tw
Telephone: +886-4-24730022 Fax: +886-4-24723229
Received: November 2, 2018 Peer-review started: November 2, 2018 First decision: January 5, 2019 Revised: February 23, 2019 Accepted: February 24, 2019 Article in press: February 25, 2019 Published online: February 27, 2019 Processing time: 117 Days and 3.7 Hours
Core Tip
Core tip: Formation of intraperitoneal adhesions is one of the major complications after abdominal surgery, which may lead to bowel obstruction. Thrombospondin-1 (TSP-1) is an extracellular matrix modulating glycoprotein during tissue regeneration and collagen deposition. This study evaluated the therapeutic potential of overexpressed TSP-1 in suppressing pelvic adhesion formations in rat models. We found the application of Sperafilm reduced the formation of adhesion band, and local administration of adenoviral vectors encoding TSP-1 on the injured cecum the also attenuated the severity of peritoneal adhesion score. Therefore, therapeutic approaches in inducing regional overexpression of TSP-1 may serve as alternative treatment strategies for preventing postoperative peritoneal adhesion.
