Risk factors for anastomotic fistula development after radical colon cancer surgery and their impact on prognosis

doi:10.4240/wjgs.v15.i11.2470

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Nov 27, 2023 (publication date) through Feb 16, 2026

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. Nov 27, 2023; 15(11): 2470-2481
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2470

Risk factors for anastomotic fistula development after radical colon cancer surgery and their impact on prognosis

Jun Wang, Min-Hua Li

Jun Wang, Department of Gastrointestinal Surgery, The Affiliated Hospital of Jiangnan University, Wuxi 214000, Jiangsu Province, China

Min-Hua Li, Department of Gastroenterology, The Affiliated Hospital of Jiangnan University, Wuxi 214000, Jiangsu Province, China

Author contributions: Wang J designed the study; Li MH contributed to the analysis of the manuscript; all authors were involved in the data collection and writing of this article; and all authors have read and approved the final manuscript.

Institutional review board statement: This study was reviewed and approved by the Institutional Review Board at the Affiliated Hospital of Jiangnan University.

Informed consent statement: The authors take full responsibility for the accuracy and integrity of the work. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013), and informed consent was obtained from all patients.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Data sharing statement: No additional data are available.

Corresponding author: Min-Hua Li, RN, Associate Chief Nurse, Department of Gastroenterology, The Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi 214000, Jiangsu Province, China. huqingtongzhi@163.com

Received: August 15, 2023
Peer-review started: August 15, 2023
First decision: August 31, 2023
Revised: September 5, 2023
Accepted: October 23, 2023
Article in press: October 23, 2023
Published online: November 27, 2023
Processing time: 104 Days and 0.2 Hours

ARTICLE HIGHLIGHTS

Research background

Patients are prone to complications such as anastomotic fistula after radical colon cancer surgery.

Research motivation

Postoperative complications such as anastomotic fistulas have a significant negative impact on patient prognosis.

Research objectives

This study aimed to investigate the risk factors for postoperative anastomotic fistulas and their impact on the prognosis of patients with colon cancer.

Research methods

This retrospective analysis of 488 patients with colon cancer who underwent radical surgery between April 2016 and April 2019 at our research center was summarized, and the risk factors for the development of anastomotic fistula and the impact of anastomotic fistula occurrence on patient prognosis were analyzed.

Research results

A total of 38 (7.8%) of 488 patients who underwent radical surgery for colon cancer had complications of postoperative anastomotic fistula with a mean Functional Assessment of Cancer Therapy-Colorectal score of 74.79 ± 11.86.

Research conclusions

Based on the results of our study, we present the independent risk factors affecting the development of anastomotic fistulas and the prognosis of patients with colon cancer after radical surgery. The main causes and preventive measures are also described.

Research perspectives

Based on the clinical data comparing patients who developed anastomotic fistulas with those who did not, the factors influencing the development of anastomotic fistulas in patients postoperatively were analyzed, and the prognoses of the two groups of patients were compared.