Correlation between preoperative systemic immune inflammation index, nutritional risk index, and prognosis of radical resection of liver cancer

doi:10.4240/wjgs.v15.i11.2445

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Nov 27, 2023 (publication date) through Feb 17, 2026

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Nov 27, 2023; 15(11): 2445-2455
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2445

Correlation between preoperative systemic immune inflammation index, nutritional risk index, and prognosis of radical resection of liver cancer

Jing Li, Hai-Yan Shi, Min Zhou

Jing Li, Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China

Hai-Yan Shi, Department of Radiology, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou 545001, Guangxi Zhuang Autonomous Region, China

Min Zhou, Department of Integrated Chinese and Western Medicine, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing 210009, Jiangsu Province, China

Co-first authors: Jing Li and Hai-Yan Shi.

Author contributions: Li J and Shi HY designed and conducted the research and wrote the manuscript; Zhou M provided clinical advice and supervised the report; All authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript. Li J and Shi HY contributed equally to this work as co-first authors. The reasons for designating Li J and Shi HY as co-first authors are threefold. First, the research was performed as a collaborative effort, and the designation of co-first authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability. Second, the overall research team encompassed authors with a variety of expertise and skills from different fields; thus, the designation of co-first authors best reflects this diversity. This also promotes the most comprehensive and in-depth examination of the research topic, ultimately enriching readers' understanding by offering various expert perspectives. Third, Li J and Shi HY contributed efforts of equal substance throughout the research process. The choice of these researchers as co-first authors acknowledges and respects their equal contribution, while recognizing the spirit of teamwork and collaboration on this study. To conclude, we believe that designating Li J and Shi HY as co-first authors is appropriate for our manuscript and accurately reflects our team's collaborative spirit, equal contributions, and diversity.

Supported by the Soft Science Research Project of Liuzhou Association for Science and Technology, No. 20200120; and Self-funded scientific research project of Guangxi Zhuang Autonomous Region Health Commission, No. Z20200258.

Institutional review board statement: This study was reviewed and approved by Liuzhou Hospital of Traditional Chinese Medicine.

Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.

Conflict-of-interest statement: The authors declare no conflict of interest.

Data sharing statement: Clinical data used in this study can be obtained from the corresponding author.

Corresponding author: Min Zhou, MD, Attending Doctor, Technician, Department of Integrated Chinese and Western Medicine, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, No. 42 Baiziting, Xuanwu District, Nanjing 210009, Jiangsu Province, China. cathyzhou0511@njmu.edu.cn

Received: August 30, 2023
Peer-review started: August 30, 2023
First decision: September 13, 2023
Revised: September 22, 2023
Accepted: October 17, 2023
Article in press: October 17, 2023
Published online: November 27, 2023
Processing time: 89 Days and 1.6 Hours

ARTICLE HIGHLIGHTS

Research background

The prognostic effect of radical hepatocellular carcinoma (HCC) surgery is not ideal, and clinicians urgently need a reliable evaluation index to guide further clinical interventions.

Research motivation

Prognostic indicators for HCC after radical resection are lacking. The systemic immune inflammatory index (SII) and geriatric nutritional risk index (GNRI) are effective in predicting the prognosis of tumors; however, few attempts have been made to apply them to the prognosis of HCC.

Research objectives

To analyze the relationship between the SII and GNRI and the clinicopathological features in patients undergoing radical HCC resection, we further explored the correlation between the SII and GNRI and mortality and explained the possible causes.

Research methods

This study retrospectively analyzed the SII, GNRI, and clinicopathological data in patients with HCC undergoing radical HCC resection at this research center, analyzed the relationship between the SII and GNRI and clinicopathological features, and further explored the relationship between the SII and GNRI and survival rate.

Research results

The SII > 309.14 group had a 1-year survival rate lower than that of the SII < 309.14 group. The 1-year survival rate was lower in the GNRI > 98 group than that in the GNRI < 98 group (P < 0.05).

Research conclusions

After analysis, we put forward the theory of the correlation between SII and GNRI and the mortality of HCC radical operations in China. Using available independent early case reports, the difficult problem of postoperative prognosis assessment was resolved to a certain extent.

Research perspectives

Based on the relationship between the SII and GNRI and the clinicopathological features in patients undergoing radical HCC surgery, the relationship between the SII and GNRI and the postoperative survival rate was further analyzed.