Hu CG, Hu BE, Zhu JF, Zhu ZM, Huang C. Prognostic significance of the preoperative hemoglobin to albumin ratio for the short-term survival of gastric cancer patients . World J Gastrointest Surg 2022; 14(6): 580-593 [PMID: 35979426 DOI: 10.4240/wjgs.v14.i6.580]
Corresponding Author of This Article
Chao Huang, PhD, Doctor, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi Province, China. huangchao8041@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ce-Gui Hu, Bai-E Hu, Jin-Feng Zhu, Zheng-Ming Zhu, Chao Huang, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Hu BE and Hu CG designed the study and contributed equally to this work; Hu BE, Hu CG and Zhu JF collected the clinical data; Hu BE analyzed the data and wrote the manuscript with contributions from all authors; Zhu ZM and Huang C provided critical comments for this paper; All authors read and approved the final version of the paper.
Supported byNational Natural Science Foundation of China, No. 81560389; and Key Research and Development Program of Jiangxi Province, No. 20181BBG70015.
Institutional review board statement: The study was reviewed and approved by the Medical Research Ethics Committee of the Second Affiliated Hospital of Nanchang University Institutional Review Board (Approval No. 20191130).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Huang, PhD, Doctor, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi Province, China. huangchao8041@163.com
Received: January 11, 2022 Peer-review started: January 11, 2022 First decision: March 12, 2022 Revised: March 20, 2022 Accepted: May 28, 2022 Article in press: May 28, 2022 Published online: June 27, 2022 Processing time: 166 Days and 22.7 Hours
ARTICLE HIGHLIGHTS
Research background
Hemoglobin and albumin are associated with the prognosis of gastric cancer (GC) patients. However, the prognostic value of the hemoglobin to albumin ratio (HAR) for the short-term survival of GC patients with D2 radical resection has not been studied.
Research motivation
The clinical value of the HAR in the prognosis of GC patients with D2 radical resection has not been reported. Nomogram can provide the overall probability of specific outcomes for individual patients and provide more accurate predictions than the traditional TNM staging system, thereby improving personalized treatment decisions.
Research objectives
The aim of this study was to investigate the significance of the HAR in evaluating the short-term survival of GC patients after D2 radical resection and to construct a nomogram to predict the prognosis in GC patients after surgery.
Research methods
Cox regression and Kaplan-Meier analysis was used for prognostic analysis. Logistic regression was used to analyze the relationships between HAR and the clinicopathological characteristics of the GC patients. A prognostic nomogram model for the short-term survival of GC patients was constructed by R software.
Research results
HAR was an independent risk factor for the short-term survival of GC patients. GC patients with a low HAR had a poor prognosis (P < 0.001). Low HAR was markedly related to high stage [odds ratio (OR) = 0.45 for II vs I; OR = 0.48 for III vs I], T classification (OR = 0.52 for T4 vs T1) and large tumor size (OR = 0.51 for ≥ 4 cm vs < 4 cm) (all P < 0.05). The nomogram model was based on HAR, age, CA19-9, CA125 and stage, and the C-index was 0.820.
Research conclusions
Preoperative low HAR was associated with short survival in GC patients. The prognostic nomogram model can accurately predict the short-term survival of GC patients with D2 radical resection.
Research perspectives
The significance of the HAR in evaluating the short-term survival of GC patients after D2 radical resection and to construct a nomogram to predict the prognosis in GC patients after surgery may provide a reference for the development of postoperative individualized treatment and follow-up plans.
