Zhang W, Ouyang DL, Che X. Short- and long-term outcomes of laparoscopic vs open surgery for T2 gallbladder cancer: A systematic review and meta-analysis. World J Gastrointest Surg 2022; 14(12): 1387-1396 [PMID: 36632125 DOI: 10.4240/wjgs.v14.i12.1387]
Corresponding Author of This Article
Xu Che, MD, Associate Professor, Chief Doctor, Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 113 Baohe Avenue, Longgang District, Shenzhen 518116, Guangdong Province, China. yixuetg@foxmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Dec 27, 2022; 14(12): 1387-1396 Published online Dec 27, 2022. doi: 10.4240/wjgs.v14.i12.1387
Short- and long-term outcomes of laparoscopic vs open surgery for T2 gallbladder cancer: A systematic review and meta-analysis
Wei Zhang, De-Liang Ouyang, Xu Che
Wei Zhang, Xu Che, Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, Guangdong Province, China
De-Liang Ouyang, Department of General Surgery, The Third Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421900, Hunan Province, China
Author contributions: Zhang W and Ouyang DL equally contributed to this work; Zhang W and Ouyang DL drafted the manuscript and acquired and interpreted the data; Che X designed the study and revised the manuscript.
Supported byShenzhen High-Level Hospital Construction Fund, and Sanming Project of Medicine in Shenzhen, No. SZSM202011010.
Conflict-of-interest statement: All authors report having no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: This meta-analysis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The data used in this study were derived from published studies and are anonymous. This study did not need informed consent from patients or a review by an institutional ethics committee. This meta-analysis was registered under the registration number CRD42022367334 on the systematic review registration platform PROSPERO (https://www.crd.york.ac.uk/PROSPERO/).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu Che, MD, Associate Professor, Chief Doctor, Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 113 Baohe Avenue, Longgang District, Shenzhen 518116, Guangdong Province, China. yixuetg@foxmail.com
Received: September 25, 2022 Peer-review started: September 25, 2022 First decision: October 20, 2022 Revised: October 28, 2022 Accepted: December 6, 2022 Article in press: December 6, 2022 Published online: December 27, 2022 Processing time: 93 Days and 5.6 Hours
ARTICLE HIGHLIGHTS
Research background
Although laparoscopic surgery (LS) is recommended for stage T1 gallbladder cancer (GBC), the value of LS for stage T2 GBC is still controversial.
Research motivation
This study evaluated the short- and long-term outcomes of LS in comparison to those of open surgery (OS) for stage T2 GBC.
Research objectives
As there is still a lack of evidence from high-quality multicenter randomized controlled trials, we believe that it is necessary to conduct a meta-analysis to provide an evidence-based reference for laparoscopic radical surgery of T2 GBC.
Research methods
We searched the PubMed, Embase, Cochrane Library, Ovid, Google Scholar, and Web of Science databases for published studies, with a cutoff date of September 2022.
Research results
A total of 5 studies were included with a total of 297 patients, 153 in the LS group and 144 in the OS group. Meta-analysis results showed that the LS group was better than the OS group in terms of operative time, estimated blood loss, and hospital stay, whereas there was no significant difference between the two groups in terms of blood transfusion, complications, number of lymph nodes retrieved, recurrence, and 3-year and 5-year overall and disease-free survival.
Research conclusions
The long-term outcomes of LS for T2 GBC are similar to those of OS, but LS is superior to OS in terms of operative time, intraoperative bleeding, and postoperative hospital stay.
Research perspectives
Our meta-analysis is the first to assess the efficacy of the laparoscopic approach in the treatment of stage T2 GBC and to provide a reference for clinical management.
