Published online Oct 27, 2021. doi: 10.4240/wjgs.v13.i10.1226
Peer-review started: March 20, 2021
First decision: June 3, 2021
Revised: June 15, 2021
Accepted: August 16, 2021
Article in press: August 16, 2021
Published online: October 27, 2021
Processing time: 220 Days and 2.8 Hours
Nonoperative management (NOM) is a promising therapeutic modality for patients with perforated peptic ulcer (PPU). However, the risk factors for poor efficacy and adverse events of NOM are a concern.
Prognostic factors that could enhance recovery, and reduce morbidity and mortality should be identified and investigated further in patients with PPU.
The aim of this study was to evaluate the relationship between risk factors and clinical outcome, and identify which factors can be used for risk stratification in patients with PPU.
Total 272 patients who were diagnosed with PPU and initially managed nonoperatively from January 2014 to December 2018 were enrolled. The clinical data of these patients were collected. Baseline patient characteristics and adverse outcomes were compared between the two groups.
Multivariate analyses revealed that low serum albumin level was an independent predictor for poor efficacy of NOM and adverse outcomes in patients with PPU.
Low serum albumin level may be used as an indicator to help us predict poor efficacy of NOM and adverse outcomes, and can be used for risk stratification in patients with PPU.
Low serum albumin is an independent risk factor that may predict adverse consequences of NOM for PPU.