Pavlidis ET, Mouratidou C, Marneri AG, Stavrati KE, Pavlidis TE. Value of serum procalcitonin levels and intraabdominal pressure in prognosis of severe acute pancreatitis course. World J Gastrointest Surg 2026; 18(8): 118909 [DOI: 10.4240/wjgs.118909]
Corresponding Author of This Article
Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
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Surgery
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Pavlidis ET, Mouratidou C, Marneri AG, Stavrati KE, Pavlidis TE. Value of serum procalcitonin levels and intraabdominal pressure in prognosis of severe acute pancreatitis course. World J Gastrointest Surg 2026; 18(8): 118909 [DOI: 10.4240/wjgs.118909]
World J Gastrointest Surg. Aug 27, 2026; 18(8): 118909 Published online Aug 27, 2026. doi: 10.4240/wjgs.118909
Value of serum procalcitonin levels and intraabdominal pressure in prognosis of severe acute pancreatitis course
Efstathios T Pavlidis, Christina Mouratidou, Alexandra G Marneri, Kalliopi E Stavrati, Theodoros E Pavlidis
Efstathios T Pavlidis, Theodoros E Pavlidis, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Christina Mouratidou, Alexandra G Marneri, Department of Intensive Care Unit, Hippokration General Hospital, Thessaloniki 54642, Greece
Kalliopi E Stavrati, Department of Surgical, Eugenideio Hospital, Athens 11528, Greece
Co-corresponding authors: Efstathios T Pavlidis and Theodoros E Pavlidis.
Author contributions: Pavlidis ET performed research, analyzed data and wrote the letter; Mouratidou C, Marneri AG, Stavrati KE assisted with data collection and interpretation; Pavlidis TE designed research, analyzed data and revised the letter. The co-corresponding author, Pavlidis ET, holds the position of first author, conducted research, analyzed data, and wrote the paper. He is an Associate Professor at the School of Medicine, Aristotle University of Thessaloniki, Greece, with a PhD and MSc in HPB Surgery, specialising in acute pancreatitis. In addition, the designation of two authors is also practical, because having two co-corresponding authors ensures efficient electronic communication and serves as a backup in case of technical issues. I kindly request your understanding and acceptance of this arrangement.
AI contribution statement: The manuscript did not use artificial intelligence tools.
Conflict-of-interest statement: The authors declared no potential conflicts of interest.
Corresponding author: Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Received: January 14, 2026 Revised: January 22, 2026 Accepted: February 3, 2026 Published online: August 27, 2026 Processing time: 215 Days and 1.6 Hours
Abstract
Severe acute pancreatitis is associated with significant morbidity and mortality, primarily due to infected pancreatic necrosis, systemic inflammatory response syndrome, and multiple organ dysfunction, which can result in poor clinical outcomes. The identification of early prognostic biomarkers is essential for facilitating prompt and effective multidisciplinary intervention. Serum procalcitonin, which is recognized as a biomarker indicative of bacterial infection and systemic inflammation, and intra-abdominal pressure, a measure reflecting intra-abdominal hypertension and abdominal compartment syndrome, have been studied for their potential utility in predicting disease severity, prognosis, and, ultimately, clinical outcomes.
Core Tip: Severe acute pancreatitis is a serious medical condition with a high morbidity and mortality rates, making early prognostic evaluation crucial for guiding treatment decisions. Procalcitonin levels and intra-abdominal pressure measurements serve as highly reliable biomarkers for intensive patient monitoring and the prognostic assessment of clinical outcomes of infected acute necrotizing pancreatitis.
