Wu YD, Zhu CL, Xi WW. Effect of laparoscopic resection with biodegradable stent on anastomotic leak and reoperation in colorectal cancer. World J Gastrointest Surg 2026; 18(6): 120732 [DOI: 10.4240/wjgs.120732]
Corresponding Author of This Article
Wei-Wei Xi, Chief Physician, General Surgery Ward Four (The Second Department of Gastroenterology), The First People’s Hospital of Chuzhou, No. 12 Zhongyou Lane, Gulou Street, Langya District, Chuzhou 239000, Anhui Province, China. m13615509850@163.com
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Gastroenterology & Hepatology
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Wu YD, Zhu CL, Xi WW. Effect of laparoscopic resection with biodegradable stent on anastomotic leak and reoperation in colorectal cancer. World J Gastrointest Surg 2026; 18(6): 120732 [DOI: 10.4240/wjgs.120732]
World J Gastrointest Surg. Jun 27, 2026; 18(6): 120732 Published online Jun 27, 2026. doi: 10.4240/wjgs.120732
Effect of laparoscopic resection with biodegradable stent on anastomotic leak and reoperation in colorectal cancer
Ya-Dong Wu, Chun-Lin Zhu, Wei-Wei Xi
Ya-Dong Wu, Chun-Lin Zhu, Wei-Wei Xi, General Surgery Ward Four (The Second Department of Gastroenterology), The First People’s Hospital of Chuzhou, Chuzhou 239000, Anhui Province, China
Author contributions: Wu YD and Zhu CL contributed to research design; Wu YD contributed to data collection, data analysis, and paper writing; Zhu CL contributed to funding application, ethical review, copyright and licensing, and follow-up; Xi WW was responsible for reviewing and editing, and communication coordination. All authors have read and approve the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First People’s Hospital of Chuzhou, No. (2026) Lunshen [Biology] (21).
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No other data available.
Corresponding author: Wei-Wei Xi, Chief Physician, General Surgery Ward Four (The Second Department of Gastroenterology), The First People’s Hospital of Chuzhou, No. 12 Zhongyou Lane, Gulou Street, Langya District, Chuzhou 239000, Anhui Province, China. m13615509850@163.com
Received: March 10, 2026 Revised: April 7, 2026 Accepted: April 23, 2026 Published online: June 27, 2026 Processing time: 104 Days and 15.6 Hours
Abstract
BACKGROUND
Anastomotic leakage is highly prevalent after laparoscopic radical resection for colorectal cancer, and traditional intestinal bypass surgery is prone to complications and impairs patients’ quality of life. In situ bypass with biodegradable intestinal stents is a novel preventive method, and this study hypothesizes that the combined procedure can reduce postoperative anastomotic leakage and reoperation rates.
AIM
To investigate efficacy of laparoscopic resection plus biodegradable stent bypass for colorectal cancer leakage and reoperation.
METHODS
Clinical data of 120 colorectal cancer patients treated from December 2022 to December 2025 were retrospectively analyzed. Patients were non-randomly assigned to the observation group (n = 60, laparoscopic resection with biodegradable stent bypass) and control group (n = 60, laparoscopic resection alone) according to the surgical treatment plan selected by patients and their families combined with clinical physician evaluation. Anastomotic leakage, reoperation rates, operative outcomes, recovery parameters, and complications were compared. All patients completed 12-month follow-up.
RESULTS
The observation group demonstrated significantly lower anastomotic leakage (1.67% vs 11.67%) and reoperation rates (0% vs 10.00%) compared to controls (both P < 0.05). Operation time and blood loss were comparable between groups (P > 0.05). However, gastrointestinal function recovery (2.8 ± 0.6 days vs 4.2 ± 0.8 days) and hospital stay (7.2 ± 1.5 days vs 10.5 ± 2.3 days) were significantly shorter in the observation group (both P < 0.05). Overall postoperative complications were also reduced (11.7% vs 28.3%, P < 0.05). No stent-related adverse events occurred during follow-up.
CONCLUSION
Laparoscopic resection combined with in situ biodegradable intestinal stent bypass effectively reduces anastomotic leakage and reoperation rates in colorectal cancer patients, accelerates postoperative recovery, and demonstrates favorable safety.
Core Tip: Laparoscopic colorectal cancer resection combined with in situ biodegradable intestinal stent bypass markedly lowers postoperative anastomotic leakage and reoperation rates, accelerates gastrointestinal recovery, reduces overall complications, and shows excellent safety without increasing surgical trauma, thus deserving wide clinical adoption for colorectal cancer treatment, especially in high-risk patients.
