Fan WJ, Feng XX, Zhang ZC, Xiang S, Zhang WG, Wang Y, Liu M. Intraductal papillary neoplasm of the left intrahepatic bile duct found during early gastric cancer treatment: A case report. World J Gastrointest Surg 2026; 18(6): 119218 [DOI: 10.4240/wjgs.119218]
Corresponding Author of This Article
Mei Liu, Professor, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. fliumei@126.com
Research Domain of This Article
Gastroenterology & Hepatology
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case-report
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Fan WJ, Feng XX, Zhang ZC, Xiang S, Zhang WG, Wang Y, Liu M. Intraductal papillary neoplasm of the left intrahepatic bile duct found during early gastric cancer treatment: A case report. World J Gastrointest Surg 2026; 18(6): 119218 [DOI: 10.4240/wjgs.119218]
World J Gastrointest Surg. Jun 27, 2026; 18(6): 119218 Published online Jun 27, 2026. doi: 10.4240/wjgs.119218
Intraductal papillary neoplasm of the left intrahepatic bile duct found during early gastric cancer treatment: A case report
Mei Liu, Ying Wang, Wan-Guang Zhang, Shuai Xiang, Zhi-Cheng Zhang, Xin-Xia Feng, Wen-Juan Fan
Wen-Juan Fan, Xin-Xia Feng, Zhi-Cheng Zhang, Mei Liu, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Shuai Xiang, Wan-Guang Zhang, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Ying Wang, Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Co-first authors: Wen-Juan Fan and Xin-Xia Feng.
Author contributions: Fan WJ reviewed the literature and contributed to the manuscript drafting and imaging data interpretation; Feng XX performed the endoscopy and analyzed the imaging findings and endoscopic images; Fan WJ and Feng XX contributed equally to this article, they are the co-first authors of this manuscript; Zhang ZC performed the endoscopic retrograde cholangiopancreatography and EyeMaxÔ; Xiang S and Zhang WG performed the surgery; Wang Y was responsible for the pathological analysis; Liu M was responsible for revising the manuscript for important intellectual content; and all authors read and approved the final version for submission and publication.
Supported by the National Natural Science Foundation of China, No. 82100568.
Informed consent statement: Informed consent was obtained from the patient for the publication of this report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Mei Liu, Professor, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. fliumei@126.com
Received: January 23, 2026 Revised: January 30, 2026 Accepted: March 13, 2026 Published online: June 27, 2026 Processing time: 148 Days and 20.1 Hours
Abstract
BACKGROUND
Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease of the bile duct. It is characterized by a papillary growth within the bile duct lumen. IPNB was formally recognized as a distinct disease entity in 2010, and its etiology remains unknown. IPNB is a complex disease and generally requires multidisciplinary investigation.
CASE SUMMARY
We report the case of a 67-year-old patient who was asymptomatic but diagnosed with IPNB during treatment of early gastric cancer due to an obvious elevation of γ-glutamyl transpeptidase. Computed tomography, magnetic resonance cholangiopancreatography, endoscopic ultrasonography, and endoscopic retrograde cholangiopancreatography with EyeMaxÔ direct visualization system were crucial for the diagnosis of IPNB. Hepatic surgery was performed, and the patient was discharged without complications.
CONCLUSION
IPNB is a complicated disease and difficult to diagnose, especially when the patient is asymptomatic. Aggressive surgical resection can achieve adequate clinical outcomes, particularly when IPNB is diagnosed in early stages.
Core Tip: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease of the bile duct. We report the management of a 67-year-old patient who was asymptomatic but diagnosed with IPNB during treatment of early gastric cancer. Multiple imaging modalities were required to successfully diagnose the patient with IPNB. After successful hepatic surgery the patient was discharged without complications. Asymptomatic presentation of IPNB is particularly complicated to diagnose, but aggressive surgical resection can result in satisfactory patient outcomes.
