Yu ZH, Ling CR, Yu JY, Zhang QH, Wei SS. Long-term disease-free survival following preoperative diagnosis and laparoscopic radical resection for Meckel’s diverticulum adenocarcinoma: A case report. World J Gastrointest Surg 2026; 18(1): 114022 [DOI: 10.4240/wjgs.v18.i1.114022]
Corresponding Author of This Article
Jun-Ying Yu, Chief Physician, Department of Colorectal Surgery, Guangxi Medical Science Academy and Guangxi Zhuang Autonomous Region People’s Hospital, No. 6 Taoyuan Road, Qingxiu District, Nanning 530000, Guangxi Zhuang Autonomous Region, China. 1556385026@qq.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jan 27, 2026; 18(1): 114022 Published online Jan 27, 2026. doi: 10.4240/wjgs.v18.i1.114022
Long-term disease-free survival following preoperative diagnosis and laparoscopic radical resection for Meckel’s diverticulum adenocarcinoma: A case report
Ze-Hao Yu, Chun-Run Ling, Jun-Ying Yu, Qiu-Huan Zhang, Department of Colorectal Surgery, Guangxi Medical Science Academy and Guangxi Zhuang Autonomous Region People’s Hospital, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Shan-Shan Wei, Department of Anesthesiology, Guangxi Medical Science Academy and Guangxi Zhuang Autonomous Region People’s Hospital, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Co-first authors: Ze-Hao Yu and Chun-Run Ling.
Co-corresponding authors: Jun-Ying Yu and Qiu-Huan Zhang.
Author contributions: Yu ZH and Ling CR contributed equally to this work as co-first authors. Yu ZH and Ling CR designed the research and wrote the original draft; Wei SS contributed to data collection and patient follow-up; Zhang QH and Yu JY contributed equally to this work as co-corresponding authors, and were responsible for study conception, project supervision, and critical revision of the manuscript. All authors have read and approved the final manuscript to be published and agree to be accountable for all aspects of the work.
Supported by the Natural Science Foundation Project of Guangxi, No. 2023GXNSFBA026003.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun-Ying Yu, Chief Physician, Department of Colorectal Surgery, Guangxi Medical Science Academy and Guangxi Zhuang Autonomous Region People’s Hospital, No. 6 Taoyuan Road, Qingxiu District, Nanning 530000, Guangxi Zhuang Autonomous Region, China. 1556385026@qq.com
Received: September 12, 2025 Revised: September 30, 2025 Accepted: November 24, 2025 Published online: January 27, 2026 Processing time: 133 Days and 20.8 Hours
Abstract
BACKGROUND
Meckel’s diverticulum (MD) is most commonly encountered during emergency interventions for complications or as an incidental finding during an unrelated procedure. Definitive pre-operative diagnosis of MD-associated adenocarcinoma, permitting radical resection, is very rare in clinical practice.
CASE SUMMARY
A 36-year-old male presented with recurrent dark-red hematochezia. Initial gastroscopy, colonoscopy, computed tomography, and tumor marker assessments were unremarkable. A technetium-99m pertechnetate Meckel scan (Meckel scan) revealed ectopic gastric mucosa, suggesting an MD. Double-balloon enteroscopy revealed an ulcerative stricture in the ileum, and biopsy confirmed a moderately differentiated adenocarcinoma. The patient underwent laparoscopic radical small bowel resection. Histopathology confirmed pT3N0M0, stage IIA (the American Joint Committee on Cancer 8th edition) moderately differentiated adenocarcinoma with lymphovascular invasion. Adjuvant chemotherapy was administered postoperatively. No recurrence or metastasis was observed during a 36-month follow-up.
CONCLUSION
For recurrent obscure gastrointestinal hemorrhage, combined Meckel scan and double-balloon enteroscopy is critical for diagnosing MD-associated, enabling curative resection.
Core Tip: This case report describes the pre-operative diagnosis of Meckel’s-diverticulum-associated adenocarcinoma identified by technetium-99m pertechnetate scanning and double-balloon enteroscopy. The patient underwent laparoscopic radical small-bowel resection (R0, 19 lymph nodes), based on the National Comprehensive Cancer Network guidelines, followed by adjuvant chemotherapy. Despite these high-risk features, 36 months of disease-free survival was achieved, highlighting a potential new diagnostic and therapeutic approach for this rare malignancy.
