Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2025; 17(7): 103938
Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.103938
Investigation and analysis of 3-year survival and influencing factors in patients with primary gastric cancer
Jin Gan, Xiong Yu, Xin-Xing Duan
Jin Gan, Xiong Yu, Xin-Xing Duan, General Surgery Center, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People’s Hospital, Jiujiang 332000, Jiangxi Province, China
Author contributions: Gan J designed the study, Gan J and Yu X contributed to the analysis of the manuscript; Gan J and Duan XX were involved in the data collection and writing of this article; and all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Jiujiang No. 1 People’s Hospital, approval No. JJSDYRMYY-YXLL-2024-239.
Informed consent statement: All study participants and their legal guardians provided written informed consent before recruitment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Xing Duan, PhD, General Surgery Center, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No. 1 People’s Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang 332000, Jiangxi Province, China. dxx15270555945@yeah.net
Received: March 12, 2025
Revised: April 11, 2025
Accepted: May 19, 2025
Published online: July 27, 2025
Processing time: 133 Days and 3.2 Hours
Abstract
BACKGROUND

This study explores the 3-year survival outcomes and associated influencing factors in patients with primary gastric cancer treated via laparoscopic surgery, providing meaningful guidance for clinical management.

AIM

To evaluate and analyze the 3-year survival outcomes and associated risk factors in patients with primary gastric cancer who underwent laparoscopic surgery.

METHODS

A total of 100 patients with primary gastric cancer who underwent laparoscopic surgery at our hospital between January 2019 and December 2021 were enrolled. These patients were monitored for 3 years, and their survival statuses were recorded. Patients were categorized into survival and non-survival groups based on their outcomes. Data on sex, age, American Society of Anesthesiologists classification, tumor size, depth of invasion, postoperative adjuvant radio-chemotherapy, postoperative carcinoembryonic antigen (CEA) levels, and other clinical parameters were collected and contrasted across groups to identify factors impacting 3-year survival.

RESULTS

After a 3-year follow-up, the survival rate was 73.00% (73 of 100 patients). No significant differences were observed in sex, tumor location, alcohol consumption, smoking status, tumor differentiation, histological type, intraoperative blood loss, or surgical outcomes between patients with varying prognoses (P > 0.05). However, notable disparities were found in age, American Society of Anesthesiologists classification, tumor-node-metastasis (TNM) stage, tumor size, depth of invasion, lymph node metastasis, lymph node dissection, postoperative adjuvant radio-chemotherapy, postoperative CEA levels, surgical duration, extent of gastric resection, and postoperative complications (P < 0.05). Multivariate logistic regression analysis identified age, TNM stage, tumor size, depth of invasion, lymph node metastasis, lymph node dissection, postoperative adjuvant radio-chemotherapy, postoperative CEA levels, surgical duration, extent of gastric resection, and postoperative complications as independent predictors of 3-year survival in patients with primary gastric cancer following laparoscopic surgery (P < 0.05).

CONCLUSION

The 3-year survival outcome for patients undergoing laparoscopic surgery for primary gastric cancer was 73.00%. Key determinants of survival included age, TNM stage, tumor size, depth of invasion, and lymph node metastasis. This analysis of 3-year survival and its influencing factors offers novel perspectives for optimizing clinical interventions in patients with primary gastric cancer treated via laparoscopic surgery.

Keywords: Primary gastric cancer; Laparoscopic surgery; Survival; Influencing factors; Carcinoembryonic antigen

Core Tip: This study analyzed the 3-year survival rate and influencing factors of primary gastric cancer patients after laparoscopic surgery, offering guidance for clinical management. A retrospective study of 100 patients (2019-2021) showed a 73.00% survival rate. Multivariate analysis found key survival factors: Age, tumor-node-metastasis stage, tumor size, depth of invasion, and lymph node metastasis. These findings provide new perspectives to improve the prognosis of primary gastric cancer patients after laparoscopic surgery and emphasize the importance of multidisciplinary teamwork and individualized treatment plans in enhancing patients’ survival rates and quality of life.