Lei ML, Dong LL, Yu YB. Anastomotic leak after ileocolic resection for Crohn’s disease: The latest evidence. World J Gastrointest Surg 2025; 17(7): 100766 [DOI: 10.4240/wjgs.v17.i7.100766]
Corresponding Author of This Article
Yan-Bo Yu, MD, PhD, Doctor, Professor, Department of Gastroenterology, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. yuyanbo2000@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2025; 17(7): 100766 Published online Jul 27, 2025. doi: 10.4240/wjgs.v17.i7.100766
Anastomotic leak after ileocolic resection for Crohn’s disease: The latest evidence
Miao-Lin Lei, Li-Li Dong, Yan-Bo Yu
Miao-Lin Lei, Yan-Bo Yu, Department of Gastroenterology, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Li-Li Dong, Department of Gastroenterology, Affiliated Qingdao Third People’s Hospital, Qingdao University, Qingdao 266001, Shandong Province, China
Author contributions: Lei ML performed the bibliographic search; Lei ML and Dong LL designed the overall concept and outline of the manuscript; Yu YB revised the article critically for important intellectual content; and all authors approved the final version of the manuscript.
Supported by National Natural Science Foundation of China, No. NSFC 82070540; the Taishan Scholars Program of Shandong Province, No. tsqn202211309; and ECCM Program of Clinical Research Center of Shandong University, No. 2021SDUCRCB003.
Conflict-of-interest statement: The authors certify that they have no conflicts of interest related to this work.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Bo Yu, MD, PhD, Doctor, Professor, Department of Gastroenterology, Laboratory of Translational Gastroenterology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. yuyanbo2000@126.com
Received: August 26, 2024 Revised: March 8, 2025 Accepted: March 24, 2025 Published online: July 27, 2025 Processing time: 331 Days and 20.6 Hours
Abstract
Studies have indicated that approximately half of individuals with Crohn’s disease (CD) may undergo surgery at some point during their lifetime. Ileocolic resection (ICR) is the most frequently performed procedure for treating CD. Addressing anastomotic leak (AL) remains a critical focus in the perioperative and postoperative care of CD patients. A research study published in the World Journal of Gastrointestinal Surgery by Cwaliński et al included 77 individuals who had open ICR and primary stapled anastomosis to assess the risk factors linked to anastomotic insufficiency. At present, research on anastomotic insufficiency has focused on AL. Therefore, this editorial mainly analyzes the current risk factors linked to AL after ICR and discusses potential prevention strategies. We comprehensively consider risk factors such as body weight, medication use, surgical history, smoking, penetrating behaviour, and albumin levels to stratify patient risk. Based on recent research insights, we propose that individualized surgical timing, approaches, and techniques should be selected according to the patient's risk level.
Core Tip: Anastomotic leak (AL) frequently occurs as a complication following ileocolic resection. Early warning of its high-risk factors facilitates the adoption of effective, targeted strategies to mitigate the occurrence of AL and optimize surgical quality. The prevention of AL plays a crucial role in the postoperative management of Crohn's disease, contributing significantly to patient outcomes.
