Fan YH, Wang MW, Gao YN, Li WM, Jiao Y. Genetic and environmental factors influencing Crohn’s disease. World J Gastrointest Surg 2025; 17(3): 98526 [DOI: 10.4240/wjgs.v17.i3.98526]
Corresponding Author of This Article
Yan Jiao, MD, PhD, Doctor, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Mar 27, 2025; 17(3): 98526 Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.98526
Genetic and environmental factors influencing Crohn’s disease
Ye-Hui Fan, Ming-Wei Wang, Yu-Ning Gao, Wen-Mao Li, Yan Jiao
Ye-Hui Fan, Department of The First Operation Room, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Ming-Wei Wang, Ministry of Health Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130000, Jilin Province, China
Yu-Ning Gao, Department of Gastrointestinal Surgery, Changchun Central Hospital, Changchun 130000, Jilin Province, China
Wen-Mao Li, Department of Rehabilitation, The Second Hospital of Jilin University, Changchun 130000, Jilin Province, China
Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiao Y designed the overall concept and outline of the manuscript; Jan YH contributed to the discussion and design of the manuscript; Fan YH, Wang MW, Gao YN, and Li WM contributed to the writing, and editing the manuscript, illustrations, and review of literature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Jiao, MD, PhD, Doctor, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Received: June 28, 2024 Revised: December 14, 2024 Accepted: January 6, 2025 Published online: March 27, 2025 Processing time: 240 Days and 22.7 Hours
Abstract
This editorial discusses Pellegrino and Gravina's essay. Crohn’s disease (CD) is a complex and multifactorial disease that is influenced by a combination of genetic and environmental factors. While genetic factors play a key role in the development of the disease, environmental factors also play a significant role in influencing the risk of developing CD. By looking at present understanding of CD pathogenesis, we emphasize the important factors involved in the development of this illness, such as nucleotide-binding oligomerization domain-2, smoking, and vitamin D. Understanding the interplay between genetic and environmental factors is crucial for developing effective strategies for preventing and treating this chronic inflammatory bowel disease.
Core Tip: The link and complicated mechanisms between Crohn’s disease (CD), nucleotide-binding oligomerization domain-2, smoking, and vitamin D is complex and poorly understood. In addition to genetic and environmental factors, the interaction between the two is also thought to play a role in the development of CD. Furthermore, the consequences of CD differ from person to person, emphasizing the importance of individual therapy. Individualized treatment, including surgery and medications, is important.
