Perioperative chemotherapy strategies in diffuse gastric cancer

doi:10.4240/wjgs.v17.i1.101326

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Jan 27, 2025 (publication date) through Feb 27, 2026

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jan 27, 2025; 17(1): 101326
Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.101326

Perioperative chemotherapy strategies in diffuse gastric cancer

Niloufar Salehi, Maria Alqamish, Rasa Zarnegar

Niloufar Salehi, Maria Alqamish, Rasa Zarnegar, Department of Surgery, Division of Endocrine & Minimally Invasive Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY 10128, United States

Author contributions: Salehi N, Alqamish M, and Zarnegar R were involved in writing the paper and approved the final version.

Conflict-of-interest statement: Dr. Rasa Zarnegar works as a consultant for Intuitive, Medtronic, and Beckton-Dickenson. Drs. Niloufar Salehi and Maria Alqamish have no conflicts of interest or financial ties to disclose.

Corresponding author: Rasa Zarnegar, FACS, MD, Professor, Department of Surgery, Division of Endocrine & Minimally Invasive Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 E. 68^th Street, New York, NY 10128, United States. raz2002@med.cornell.edu

Received: September 14, 2024
Revised: November 22, 2024
Accepted: December 2, 2024
Published online: January 27, 2025
Processing time: 104 Days and 3.6 Hours

Abstract

This study reviews the findings of a recent study by Li et al, which demonstrated that perioperative chemotherapy benefits patients with diffuse-type gastric cancer compared to surgery alone. Despite potential biases, the study supports the inclusion of perioperative chemotherapy in treatment guidelines. Neoadjuvant and adjuvant chemotherapy may also provide similar survival outcomes, allowing for flexible treatment planning.

Keywords: Gastric cancer; Neoadjuvant chemotherapy; Adjuvant chemotherapy; Gastric adenocarcinoma; Survival

Core Tip: Perioperative chemotherapy is potentially effective for treating diffuse-type gastric cancer, supporting its continued inclusion in treatment guidelines. However, further research is needed to define optimal therapeutic strategies and improve patient outcomes.