Zhang X, Zhu HY, Yuan M. Efficacy and safety of B-ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer: Systematic review and meta-analysis. World J Gastrointest Surg 2024; 16(9): 2986-2995 [PMID: 39351568 DOI: 10.4240/wjgs.v16.i9.2986]
Corresponding Author of This Article
Xiong Zhang, MM, Department of Nursing, Guizhou Nursing Vocational College, No. 338 Dazhi Road, Huaxi District, Guiyang 550025, Guizhou Province, China. zhangxiong_199608@163.com
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2024; 16(9): 2986-2995 Published online Sep 27, 2024. doi: 10.4240/wjgs.v16.i9.2986
Efficacy and safety of B-ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer: Systematic review and meta-analysis
Xiong Zhang, Hong-Yi Zhu, Ming Yuan
Xiong Zhang, Hong-Yi Zhu, Department of Nursing, Guizhou Nursing Vocational College, Guiyang 550025, Guizhou Province, China
Ming Yuan, Department of Hepatobiliary Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Author contributions: Zhang X wrote the manuscript; Zhu HY collected the data; Yuan M guided the study; all authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors declare no conflicts of interest.
PRISMA 2009 Checklist statement: This study strictly followed PRISMA 2009 inventory guidelines to ensure transparency and reproducibility of the systematic review and meta-analysis process. We follow PRISMA standards in literature screening, data extraction and analysis to improve the quality and credibility of research and provide readers with clear and comprehensive findings and conclusions.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiong Zhang, MM, Department of Nursing, Guizhou Nursing Vocational College, No. 338 Dazhi Road, Huaxi District, Guiyang 550025, Guizhou Province, China. zhangxiong_199608@163.com
Received: May 7, 2024 Revised: July 30, 2024 Accepted: August 1, 2024 Published online: September 27, 2024 Processing time: 133 Days and 23.5 Hours
Abstract
BACKGROUND
Primary liver cancer is one of the most lethal malignancies in the world. Traditional treatment methods have limitations in terms of efficacy and safety. Radiofrequency ablation (RFA) guided by B-ultrasound, as a minimally invasive treatment, has attracted increasing attention in the treatment of primary liver cancer in recent years.
AIM
To study the efficacy and safety of RFA were compared with those of traditional surgery (TS) for treating small liver cancer.
METHODS
At least 2 people were required to search domestic and foreign public databases, including foreign databases such as EMBASE, PubMed and the Cochrane Library, and Chinese databases such as the China National Knowledge Infrastructure database, China Biomedical Literature database, Wanfang database and VIP database. Controlled trials of RFA vs conventional surgery for small liver cancer were retrieved from January 2008 to January 2023. They were screened and evaluated according to the quality evaluation criteria in the Cochrane Handbook of Systematic Reviews. The meta-analysis was performed using RevMan 5.3 software.
RESULTS
A total of 10 studies were included in this study, including 1503 patients in the RFA group and 1657 patients in the surgery group. The results of the meta-analysis showed that there was no significant difference in 1-year overall survival between the two groups (P > 0.05), while the 3-year and 5-year overall survival rates and 1-year, 3-year and 5-year tumor-free survival rates in the surgery group were greater than those in the RFA group (P < 0.05). In terms of complications, the incidence of complications in the RFA group was lower than that in the surgery group (P < 0.05).
CONCLUSION
In terms of long-term survival, TS is better than RFA for small liver cancer patients. However, RFA has fewer complications and is safer.
Core Tip: To evaluate the efficacy and safety of B-ultrasound-guided radiofrequency ablation (RFA) in the treatment of primary liver cancer by meta-analysis. This study systematically searched a variety of medical databases, screened out clinical trials and observational studies that met the criteria, extracted relevant data, and used statistical methods for comprehensive analysis. The key indicators of RFA, such as tumor ablation success rate, patient survival rate, complication rate and postoperative recurrence rate, were mainly concerned. Through comparison and analysis, the aim is to provide more powerful evidence support for clinical practice, optimize the treatment strategy of primary liver cancer, and improve the quality of life and prognostic effect of patients.
