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World J Gastrointest Surg. Mar 27, 2024; 16(3): 658-669
Published online Mar 27, 2024. doi: 10.4240/wjgs.v16.i3.658
Applications of gastric peroral endoscopic myotomy in the treatment of upper gastrointestinal tract disease
Shi-Yu Chang, Guo-Hua Jin, Hai-Bo Sun, Dong Yang, Tong-Yu Tang
Shi-Yu Chang, Guo-Hua Jin, Hai-Bo Sun, Dong Yang, Tong-Yu Tang, Department of Gastroenterology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Co-first authors: Shi-Yu Chang and Guo-Hua Jin.
Author contributions: Chang SY and Jin GH wrote the paper, provided equal contributions to the article; Sun HB and Yang D collected relevant data and conducted analysis; Tang TY provided research directions and reviewed the paper; all the authors report no relevant conflicts of interest for this article. The completion of this paper is the result of the joint efforts and significant contributions of both authors, Chang SY and Jin GH. They have played an indispensable role at every stage of this research project, from the initial conceptualization and experimental design to data analysis and interpretation of results, as well as the final drafting and revision of the paper. Both authors have invested equal amounts of time and energy into the work. Their collaboration has been equal and close-knit, and thus, in this paper, Chang SY and Jin GH should be recognized as co-first authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tong-Yu Tang, MD, Chief Physician, Department of Gastroenterology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. tangty@jlu.edu.cn
Received: December 19, 2023
Peer-review started: December 19, 2023
First decision: January 9, 2024
Revised: January 15, 2024
Accepted: February 8, 2024
Article in press: February 8, 2024
Published online: March 27, 2024
Processing time: 93 Days and 19.5 Hours
Abstract

Gastric peroral endoscopic myotomy (G-POME) is an emerging minimally invasive endoscopic technique involving the establishment of a submucosal tunnel around the pyloric sphincter. In 2013, Khashab et al used G-POME for the first time in the treatment of gastroparesis with enhanced therapeutic efficacy, providing a new direction for the treatment of gastroparesis. With the recent and rapid development of G-POME therapy technology, progress has been made in the treatment of gastroparesis and other upper digestive tract diseases, such as congenital hypertrophic pyloric stenosis and gastric sleeve stricture, with G-POME. This article reviews the research progress and future prospects of G-POME for the treatment of upper digestive tract gastrointestinal diseases.

Keywords: Gastric peroral endoscopic myotomy; Upper digestive tract diseases; Gastroparesis; Congenital hypertrophic pyloric stenosis; Gastric sleeve stricture

Core Tip: Since the application of gastric peroral endoscopic myotomy (G-POME) in gastroparesis in 2013, it has been widely promoted and applied by many centers. More and more centers are using G-POME to treat gastroparesis, congenital hypertrophic pyloric stenosis, and other upper gastrointestinal diseases. This article reviews the technological progress of G-POME and its application in upper gastrointestinal diseases.