Cognitive clarity in colon surgery: The dexmedetomidine advantage

Abstract

Colon cancer is one of the most prevalent cancers globally, especially in the older age group. A large number of older patients undergoing surgery for colon cancer suffer from postoperative cognitive dysfunction (POCD). The trial by Bu et al demonstrated that dexmedetomidine (Dex) significantly reduced the incidence of POCD compared to placebo in individuals undergoing colon cancer surgery. Additionally, better cerebral oxygenation and lower cerebral injury markers were reported with the use of Dex. The trial has some limitations, such as a single-center design and a smaller sample size, and further studies with larger patient populations and robust multi-center designs are warranted to establish these findings.

Keywords: Dexmedetomidine; Colon cancer; Old age group; Postoperative cognitive dysfunction; Cerebral injury

Core Tip: This letter highlights the trial by Bu et al, which reveals that dexmedetomidine can significantly reduce the incidence of postoperative cognitive dysfunction and improve cerebral oxygenation in elderly patients undergoing radical colon cancer surgery. Despite several limitations, the study reflects profound clinical implications while suggesting additional research and innovative approaches to treatment.