Published online Dec 27, 2023. doi: 10.4240/wjgs.v15.i12.2757
Peer-review started: September 14, 2023
First decision: October 8, 2023
Revised: October 23, 2023
Accepted: November 25, 2023
Article in press: November 25, 2023
Published online: December 27, 2023
Processing time: 104 Days and 2.6 Hours
Peptic ulcer (PU) is an abnormal phenomenon in which there is rupture of the mucosa of the digestive tract, which not only affects patients' normal life but also causes an economic burden due to its high medical costs.
To investigate the efficacy of pantoprazole (PPZ) plus perforation repair in patients with PU and its effect on the stress response.
The study subjects were 108 PU patients admitted between July 2018 and July 2022, including 58 patients receiving PPZ plus perforation repair [research group (RG)] and 50 patients given simple perforation repair [control group (CG)]. The efficacy, somatostatin (SS) concentration, stress reaction [malondialdehyde (MDA), lipid peroxide (LPO)], inflammatory indices [tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-1β], recurrence, and complications (perforation, hemorrhage, and pyloric obstruction) were compared.
The overall response rate was higher in the RG than in the CG. Patients in the RG had markedly elevated SS after treatment, which was higher than that of the CG, while MDA, LPO, TNF-, CRP, and IL-1β were significantly reduced to lower levels than those in the CG. Lower recurrence and complication rates were identified in the RG group.
Therefore, PPZ plus perforation repair is conducive to enhancing treatment outcomes in PU patients, reducing oxidative stress injury and excessive inflammatory reactions, and contributing to low recurrence and complication rates.
Core Tip: Peptic ulcer (PU), as a chronic disease, may cause complications such as perforation, upper gastrointestinal bleeding, and rarely gastric outlet obstruction. Risk factors such as advanced age, a history of PU, Helicobacter pylori infection, and the use of nonsteroidal anti-inflammatory drugs further increase the risk of developing the disease. To further reduce the associated negative effects of the disease, this study aims to explore and seek new therapeutic models to improve the management of the disease.