Zhan WL, Liu L, Jiang W, He FX, Qu HT, Cao ZX, Xu XS. Immunoglobulin G4-related disease in the sigmoid colon in patient with severe colonic fibrosis and obstruction: A case report. World J Gastrointest Surg 2022; 14(10): 1169-1178 [PMID: 36386398 DOI: 10.4240/wjgs.v14.i10.1169]
Corresponding Author of This Article
Xiang-Shang Xu, MD, PhD, Associate Professor, Doctor, Department of Gastrointestinal Surgery, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. xsxu@tjh.tjmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhan WL, Liu L, Jiang W, He FX, Qu HT, Cao ZX, Xu XS. Immunoglobulin G4-related disease in the sigmoid colon in patient with severe colonic fibrosis and obstruction: A case report. World J Gastrointest Surg 2022; 14(10): 1169-1178 [PMID: 36386398 DOI: 10.4240/wjgs.v14.i10.1169]
Wen-Li Zhan, Liang Liu, Wei Jiang, Fang-Xun He, Zhi-Xin Cao, Xiang-Shang Xu, Department of Gastrointestinal Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Hai-Tao Qu, Anorectal Disease Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, Henan Province, China
Author contributions: Zhan WL and Xu XS contributed to conceptualization, data curation, formal analysis, investigation, and methodology; Zhan WL, Liu L, and Jiang W contributed to visualization, roles/writing-original draft, and writing-review & editing; Cao ZX and Xu XS contributed to conceptualization, project administration, supervision, and writing - review & editing; Qu HT and He FX contributed to investigation; methodology and validation.
Supported byTongji Hospital Foundation, No. 2021HGRY012; and The Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province, No. CXPJJH121003-2104.
Informed consent statement: Informed written consent was obtained from the patient and her family for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Xiang-Shang Xu, MD, PhD, Associate Professor, Doctor, Department of Gastrointestinal Surgery, Tongji Hospital, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. xsxu@tjh.tjmu.edu.cn
Received: July 10, 2022 Peer-review started: July 10, 2022 First decision: August 19, 2022 Revised: September 3, 2022 Accepted: October 18, 2022 Article in press: October 18, 2022 Published online: October 27, 2022 Processing time: 107 Days and 6.6 Hours
Abstract
BACKGROUND
Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated condition characterized by abundant IgG4 positive plasma cells and fibrosis in the affected tissues. It affects most parts of the body; however, there are not many reports on IgG4-RD involving the colon.
CASE SUMMARY
A 50-year-old man complaining of intermittent fever for more than two years was referred to our hospital. Based on various investigations before surgery, we diagnosed him with chronic perforation of the sigmoid colon caused by inflammatory change or tumor. IgG blood tests before the operation suggested IgG4-RD, and postoperative pathology confirmed this prediction.
CONCLUSION
We present a patient with IgG4-RD with colon involvement, which is an uncommon site. This report will expand the understanding of IgG4-RD in unknown tissues.
Core Tip: Immunoglobulin G4-related disease (IgG4-RD) is characterized by abundant IgG4 positive plasma cells and fibrosis in the affected tissues. It can affect most parts of the body, but there were not many reports of IgG4-RD in the intestines. This patient was an IgG4-RD case to be reported in the colon, which was identified by computed tomography, magnetic resonance imaging, pathology and blood tests of IgGs. This case report will help expand the understanding of IgG4-RD in some unknown tissues.
