Defecation disorders are crucial sequelae that impairs the quality of life of patients after conventional gastrectomy

Abstract

BACKGROUND

Defecation disorders are obscure sequelae that occurs after gastrectomy, and its implication on daily lives of patients have not been sufficiently investigated.

AIM

To examine the features of defecation disorders after gastrectomy and to explore its implication on daily lives of patients in a large cohort using the Postgastrectomy Syndrome Assessment Scale (PGSAS)-45.

METHODS

We conducted a nationwide multi-institutional study using PGSAS-45 to examine the prevalence of postgastrectomy syndrome and its impact on daily lives of patients after various types of gastrectomy. Data were obtained from 2368 eligible patients at 52 institutions in Japan. Of these, 1777 patients who underwent total gastrectomy (TG; n = 393) or distal gastrectomy (DG; n = 1384) were examined. The severity of defecation disorder symptoms, such as diarrhea and constipation, and their correlation with other postgastrectomy symptoms were examined. The importance of defecation disorder symptoms on the living states and quality of life (QOL) of postgastrectomy patients, and those clinical factors that affect the severity of defecation disorder symptoms were evaluated using multiple regression analysis.

RESULTS

Among seven symptom subscales of PGSAS-45, the ranking of diarrhea was 4^th in TG and 2^nd in DG. The ranking of constipation was 5^th in TG and 1^st in DG. The symptoms that correlated well with diarrhea were dumping and indigestion in both TG and DG; while those with constipation were abdominal pain and meal-related distress in TG, and were meal-related distress and indigestion in DG. Among five main outcome measures (MOMs) of living status domain, constipation significantly impaired four MOMs, while diarrhea had no effect in TG. Both diarrhea and constipation impaired most of five MOMs in DG. Among six MOMs of QOL domain, diarrhea impaired one MOM, whereas constipation impaired all six MOMs in TG. Both diarrhea and constipation equally impaired all MOMs in DG. Male sex, younger age, division of the celiac branch of vagus nerve, and TG, independently worsened diarrhea, while female sex worsened constipation.

CONCLUSION

Defecation disorder symptoms, particularly constipation, impair the living status and QOL of patients after gastrectomy; therefore, we should pay attention and adequately treat these relatively modest symptoms to improve postoperative QOL.

Keywords: Postgastrectomy syndrome; Defecation disorders; Quality of life; Patient-reported outcome measures; Gastrectomy

Core Tip: Symptoms of defecation disorders, such as diarrhea and constipation, are relatively modest and have not received sufficient attention among various postgastrectomy symptoms; therefore, their implication on the daily lives of patients have not been adequately investigated. We evaluated these symptoms using a nationwide multi-institutional collaborative study called the Postgastrectomy Syndrome Assessment Study. The severity of symptoms of defecation disorders were unexpectedly high and both symptoms, particularly constipation, impaired the living status and quality of life (QOL) of patients after gastrectomy; therefore, we should also pay attention and adequately treat these symptoms to improve postoperative QOL.