• Active acupressure
• Diarrhea
• Irritable bowel syndrome
• Nurse led Trial
• Nursing Care.
• Randomized Controlled Trial
• Sham acupressure

• Alexandria University

• acupuncture
• cancer
• complementary and alternative medicine
• hiccups
• meta

• acupuncture
• elderly people
• functional constipation
• meta-analysis
• systematic review

• Acupuncture therapy
• Evolutionary medicine
• Homeostasis
• Mechanism
• Parasympathetic nervous system

• Humans
• Acupuncture Therapy/methods
• Biological Evolution
• Pain Management/methods
• Autonomic Nervous System
• Immune System
• Wound Healing

• Electroacupuncture
• PC6
• Postoperative gastrointestinal recovery
• Postoperative ileus
• ST36

• Acupuncture
• Meta-analysis
• Nausea
• Pregnancy
• Systematic review
• Vomiting

• Female
• Humans
• Pregnancy
• Acupuncture Therapy/methods
• Nausea/therapy
• Pregnancy Complications/therapy
• Randomized Controlled Trials as Topic
• Vomiting/therapy

• Complementary and integrative health (CIH)
• complementary and alternative health
• disorders of gut-brain interaction (DGBI)
• inflammatory bowel disorder
• whole person health

• acupuncture
• gastrointestinal disease
• gut microbiota
• mental disorders
• metabolic disease
• nervous system disease

• Gastrointestinal Microbiome
• Humans
• Acupuncture Therapy
• Gastrointestinal Diseases/microbiology
• Gastrointestinal Diseases/therapy
• Mental Disorders/therapy
• Mental Disorders/microbiology
• Nervous System Diseases/therapy
• Nervous System Diseases/microbiology
• Animals
• Metabolic Diseases/microbiology
• Metabolic Diseases/therapy

• Constipation/therapy
• Constipation/microbiology
• Humans
• Fecal Microbiota Transplantation/adverse effects
• Dietary Fiber/therapeutic use
• Probiotics/therapeutic use
• Probiotics/adverse effects
• Chronic Disease
• Acupuncture Therapy/methods
• Treatment Outcome
• Network Meta-Analysis
• Randomized Controlled Trials as Topic
• Quality of Life
• Laxatives/therapeutic use

• acupuncture
• colorectal surgery
• daikenchuto
• laparoscopic surgery
• lidocaine
• nonsteroidal anti-inflammatory drugs
• postoperative ileus

• Humans
• Postoperative Complications/prevention & control
• Ileus/prevention & control
• Ileus/etiology
• Risk Factors
• Chewing Gum
• Probiotics/therapeutic use
• Enhanced Recovery After Surgery

• Electroacupuncture
• Gut barrier
• Motor dysfunction
• NLRP3 inflammasome
• Parkinson's disease

• Integrated Traditional Chinese and Western Medicine
• guideline
• postoperative gastrointestinal disorder

• Humans
• Medicine, Chinese Traditional
• Integrative Medicine
• Gastrointestinal Diseases/prevention & control
• Evidence-Based Medicine

• 20JR10RA435 Gansu Province Science and Technology Foundation Project-Clinical Medicine Research Center Construction
• 22YF7FA101 Gansu Province Science and Technology Plan Project-Key research and development program

• Acupuncture
• Autonomic nervous system
• Bibliometric analysis
• CiteSpace

• Humans
• Acupuncture Therapy
• Autonomic Nervous System
• Bibliometrics
• Medicine, East Asian Traditional
• Anti-Inflammatory Agents

• Parkin
• Parkinson's disease constipation
• acupuncture
• autophagy
• rotenone
• α-Syn
• α-突触核蛋白
• 关键词
• 帕金森便秘
• 自噬
• 针灸
• 鱼藤酮

• Rats
• Animals
• Parkinson Disease/therapy
• Electroacupuncture/methods
• Rotenone/toxicity
• Constipation/therapy
• Enteric Nervous System
• Ubiquitin-Protein Ligases

• Crohn’s disease
• acupuncture
• meta-analysis
• systematic review

• Achalasia
• Acupuncture
• Esophageal manometry
• Esophageal motility

• Humans
• Esophageal Achalasia/therapy
• Manometry
• Acupuncture Therapy/adverse effects
• Esophageal Motility Disorders/diagnosis
• Esophageal Motility Disorders/etiology
• Esophageal Motility Disorders/therapy

• acupuncture
• enhanced recovery after surgery
• gastrointestinal function
• meta-analysis
• tumor

• Analgesia
• Bowel function
• Colorectal resection
• Gastrectomy
• Postoperative pain
• Transcutaneous electrical acupoint stimulation

• Pregnancy
• Child
• Female
• Humans
• Doxylamine/adverse effects
• Pyridoxine/therapeutic use
• Pyridoxine/adverse effects
• Antiemetics/therapeutic use
• Quality of Life
• Vomiting/drug therapy
• Vomiting/chemically induced
• Nausea/drug therapy
• Pregnancy Complications/drug therapy
• Acupuncture Therapy/adverse effects

• acupuncture
• digestion
• dumping syndrome
• esophagus cancer
• feeding jejunostomy
• malnourishment
• weight loss

• Humans
• Acupuncture Points
• Acupuncture Therapy/methods
• Dumping Syndrome
• Esophageal Neoplasms/complications
• Jejunostomy
• Randomized Controlled Trials as Topic
• Single-Blind Method
• Treatment Outcome

• acupuncture
• animal studies
• gastrointestinal diseases
• literature review
• stomach

• National Research Foundation of Korea
• Korea Health Industry Development Institute

In the perioperative period of biliary surgery, various factors can induce the release of a large number of inflammatory factors, leading to an imbalance in pro-inflammatory and anti-inflammatory responses and resulting in gastrointestinal (GI) dysfunction. Enhanced Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative recovery. It is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery, both of which are the basis and key for perioperative care and postoperative recovery.

To better understand the effects of Modified Xiao-Cheng-Qi decoction (MXD) on inflammatory response and GI function in the perioperative management of cholelithiasis and their correlation.

This was a prospective randomized placebo-controlled trial, in which 162 patients who received biliary tract surgery were randomly assigned to three groups: MXD group, XD group, and placebo-control group. The observed parameters included frequency of bowel sounds, time of first flatus and defecation, time of diet, and amount of activity after surgery. The serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, serum amyloid A protein (SAA), and substance P were measured by the enzyme-linked immunosorbent assay. Then, the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and inflammation.

Compared to the placebo-control, improvements in GI function were observed in the MXD groups including reduced incidence of nausea, vomiting, and bloating; and earlier first exhaust time, first defecation time, and feeding time after surgery (P < 0.05). On the 1^st and 2^nd d after surgery, IL-6, CRP and SAA levels in MXD group were lower than that in placebo control, but substance P level was higher, compared to the control (P < 0.05). Functional diarrhea occurred in both MXD and XD groups without any other adverse effects, toxic reactions, and allergic reactions. Diarrhea was relieved after the discontinuation of the investigational remedies. Bowel sounds at 12 h after surgery, the occurring time of the first flatus, first defecation, postoperative liquid diet and semi-liquid diet were significantly correlated with levels of IL-6, CRP, SAA and substance P on second day after surgery (P < 0.05).

Treatment with MXD can relieve inflammatory response and improve GI function after surgery. Moreover, there are significant correlations between them. Furthermore, it does not cause serious adverse reactions.

• Modified Xiao-cheng-qi Decoction
• Cholelithiasis
• Inflammatory response
• Gastrointestinal function
• Enhanced Recovery After Surgery
• Perioperative

• Parkinson's disease constipation
• colonic motility
• electroacupuncture
• enteric nervous system
• neuropathology

• acupuncture therapy
• adverse effect
• network meta-analysis
• radiotherapy
• systematic review

• Humans
• Acupuncture Therapy
• Network Meta-Analysis
• Radiation Injuries/etiology
• Radiation Injuries/therapy
• Radiotherapy/adverse effects

• United States
• Humans
• Male
• Adult
• Irritable Bowel Syndrome/complications
• Irritable Bowel Syndrome/therapy
• Irritable Bowel Syndrome/diagnosis
• Pilot Projects
• Acupuncture Therapy
• Diarrhea/drug therapy
• Abdominal Pain/etiology
• Abdominal Pain/therapy
• Abdominal Pain/diagnosis

Gastrointestinal dysfunction (GD) is a common complication after endotoxemia, which can further aggravate the progress of infection. Acupuncture uses metal needles of different shapes and techniques to stimulate specific points on the human body, which are effective in treating various diseases, including gastrointestinal diseases. We aimed at exploring the clinical effect of acupuncture on the recovery of visceral sensation, proximal gastric compliance, and autonomic nervous function in patients with septic GD. A total of 73 sepsis with GD patients were selected using modified single section ultrasonography combined with clinical symptoms in the First People's Hospital of Lanzhou City during 2019. The participants were randomly allocated to routine-treatment (control group) and study group receiving acupuncture. The indexes before and after treatment included gastric residue, gastric dilatation, pressure and volume, gastric compliance, autonomic nerve function, APACHE II score, and infection index were measured and compared. Before treatment, there was no significant difference in the basic information of the two groups, including gastric volume and pressure, gastric residue, gastric compliance, autonomic nerve function, and APACHE II score. After treatment, the maximum gastric volume and pressure, gastric residue, and APACHE II score of the two groups were significantly improved (P < 0.05). In addition, the maximum gastric volume and pressure of the study group were significantly higher, while gastric residual, autonomic nerve function, and APACHE II were significantly lower than those of the control group (P < 0.05). However, our results showed that acupuncture did not further reduce inflammatory markers, including white blood cells, C-reactive protein, and procalcitonin. To sum up, on the basis of basic treatment, the application of acupuncture can further improve the clinical symptoms of GD in patients with sepsis, enhance gastrointestinal motility, and improve autonomic nervous function, which is worthy of clinical application and promotion.

• Laparoscopic surgery
• Postoperative pain
• Recovery
• Transcutaneous electrical acupoint stimulation
• Transversus abdominis plane block

To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics analysis was used to survey the global changes of colonic mucosa proteins between different groups. Sixteen Sprague-Dawley (SD) male rats were randomly divided into four groups: the control group (C); the IBS-D model group (M); the syndrome differentiation acupuncture group (SD) and the traditional acupuncture group (T). IBS-D model rats were obtained using the CAS (chronic acute combining stress model) method. Comparative bioinformatics analysis of the proteomic data was analyzed using MaxQuant software, Perseus software, online tools DAVID, VENNY and STRING. Functional enrichment and network analyses revealed a close relationship between IBS-D and several biological processes including energy metabolism, muscular excitation/contraction, and both traditional acupuncture and syndrome differentiation acupuncture can reverse the impairments of normal energy metabolism. Moreover, the syndrome differentiation acupuncture can regulate the protein cluster relating inflammation, wound repair and cell protection against oxidative stress which is associated with acupuncture analgesic effect. Differentially expressed proteins Atp5a1 and Bpnt1 were selected as representative proteins and subjected to western blotting. In conclusion, our study provides further insight into the pathological and molecular mechanisms of IBS-D and acupuncture treatments, and serves as an experimental basis for clinical applications.

Diarrhea-predominant irritable bowel syndrome (IBS-D) is the most common subtype of IBS. Acupuncture is commonly used to treat IBS-D, but its effect is uncertain because of the poor quality of prior studies. This trial aims to evaluate the efficacy and safety of acupuncture treatment for IBS-D through comparisons with sham acupuncture.

This is a large-scale, multi-center, randomized, two-arm interventional clinical trial. Participants will take part in a total of 20 weeks of study, which contained 3 phases: 2-week screening, 6-week treatment, and 12-week follow-up. Based on the composite response rate of the primary endpoint in our pilot study (a sham acupuncture response rate of 27% and a true acupuncture of approximately 45%), 280 randomly allocated participants were planned. Eligible participants will be randomly assigned to the true acupuncture group and sham acupuncture group according to a ratio of 1:1, and a total of 15 sessions of treatment overall 6-week treatment period will be brought. The primary endpoint is a composite response rate at week 6, and the responder is defined as who responses in both abdominal pain intensity and stool consistency. Furthermore, composite response rates at other weeks, IBS Symptom Severity Scale, IBS Quality of Life, Adequate Relief scale, and individual IBS symptoms (abdominal pain, bloating, stool frequency) are chosen as secondary endpoints.

This trial may provide high-quality evidence for the efficacy and safety of acupuncture in the treatment of IBS-D. The results of this study will be published in peer-reviewed journals.

Chinese Clinical Trial Registry: ChiCTR2100044762. Registered on 26 March 2021.

• Acupuncture
• Diarrhea-predominant irritable bowel syndrome
• Protocol
• Randomized controlled trials

• clinical practice guidelines
• korean medicine
• scoliosis
• survey

• Humans
• Practice Patterns, Physicians'
• Preliminary Data
• Quality of Life
• Republic of Korea
• Scoliosis/surgery
• Surveys and Questionnaires

• acupuncture
• chronic fatigue syndrome
• moxibustion
• network meta-analysis
• traditional chinese medicine

• Acupuncture Therapy/methods
• Fatigue Syndrome, Chronic/therapy
• Humans
• Medicine, Chinese Traditional
• Moxibustion
• Network Meta-Analysis

After surgical treatment, the gastrointestinal function of tumor patients is inhibited for a short time. Refined nursing is beneficial to the recovery of gastrointestinal function of tumor patients after operation. Traditional Chinese medicine and Western medicine have their own advantages in the treatment of gastrointestinal dysfunction after tumor operation and the combined application of the two is more ideal. Therefore, on the premise of refined nursing, we should carefully study the efficacy of integrated traditional Chinese and Western medicine in the treatment of postoperative gastrointestinal dysfunction in tumor patients. Fifty patients with gastrointestinal dysfunction after tumor surgery admitted to Xiamen University Affiliated Zhongshan Hospital from June 2021 to August 2022 were retrospectively selected. Twenty two of them received refined care + Western medicine (control group, CG) and the other 28 received refined care + Western medicine + moxibustion and thumb-tack needle Chinese medicine (observation group, OG). We compared the recovery of gastrointestinal function, inflammatory factors, negative emotions, sleep quality, length of stay, medical expenses, and adverse reactions. The postoperative recovery effect of gastrointestinal function in the OG was better than that in the CG. The IL-8 level and TNF -α level in OG were lower than those in CG. Relative to CG, the OG had significantly low SDS scores, SAS scores, PSQ1 scores, length of hospital stay, and medical expenses. The OG incidence of adverse reactions was 28.57%; it was significantly lower than 59.09% in the CG. Refined nursing with integrated Chinese and Western medicine therapeutic interventions can promote the recovery of gastrointestinal tract function, relieve anxiety and depression, and improve sleep quality in patients with postoperative gastrointestinal dysfunction after tumor surgery.

• Acupuncture
• Chinese Medicine
• Enhanced Recovery after Surgery
• Postoperative Complications
• Review
• Surgical Outcomes

Although chemotherapy is the first-line treatment strategy for a variety of tumors, its side effects have limited its efficacy. This review summarizes the progress on the use of acupoint stimulation to combat chemotherapy-associated side effects, including chemotherapy-induced peripheral neuropathy (CIPN), cognitive impairment (CICI), and gastrointestinal toxicity (GI), as well as myelosuppression and immunosuppression. It was found that acupoint stimulation attenuated CIPN and GI by modulating the 5-hydroxytryptamine system in dorsal root ganglia, the dorsal horn of the spinal cord, and the duodenum by reducing oxidative stress and neuroinflammation. Acupoint stimulation also alleviated GI by activating vagal activity in the nucleus tractus solitarius and promoting the secretion of gastrointestinal neuropeptide hormones. Acupoint stimulation restored both bone marrow hematopoiesis and immune function to combat cancer. In addition, the combination of acupoint stimulation and chemotherapy could inhibit tumor growth by promoting tumor cell apoptosis and the enrichment of chemotherapeutic agents in tumor tissue and by modulating the tumor immune microenvironment and normalizing the vasculature. Multiple evidence also indicates that neuroimmune regulation may be involved in the effects of acupoint stimulation. In conclusion, the evidence suggests that acupoint stimulation can alleviate the side effects of chemotherapy and can also assist chemotherapeutic agents in inhibiting tumor growth, which expands the clinical application of acupoint stimulation in cancer treatment. However, more high-quality clinical studies are needed to confirm the clinical value of acupoint stimulation.

• acupoint stimulation
• acupuncture
• cancer
• chemotherapy
• neuroimmune

• acupuncture
• functional constipation
• laxative
• massage
• meta-analysis

• Bayes Theorem
• Complementary Therapies/adverse effects
• Constipation/therapy
• Humans
• Meta-Analysis as Topic
• Research Design
• Systematic Reviews as Topic

Postoperative gastrointestinal dysfunction (PGID) is a common complication arising from colorectal cancer surgery. Attributing factors, such as anesthesia, surgical retraction, and early intake of water, can inhibit gastrointestinal motility, causing constipation, reduction or absence of bowel sounds, nausea, vomiting, and other symptoms. Delayed recovery in gastrointestinal function can lead to intestinal obstructions or paralysis, anastomotic leaks, and other complications, affecting the patient’s recovery and quality of life negatively. Due to its complex pathophysiology, treatment for PGID in colorectal patients has remained a challenge. Acupuncture is an alternative therapy commonly used for postoperative recovery. This study aims to evaluate the therapeutic efficacy and safety of acupuncture on PGID. Through the complementation of acupuncture and enhanced recovery after surgery (ERAS) protocols, the advantages of acupuncture treatments could be demonstrated to promote its application in future clinical practice.

The study design is a prospective randomized controlled trial (RCT). One hundred sixty postoperative colorectal cancer patients will be recruited from Cancer Hospital Chinese Academy of Medical Sciences (CICAMS). Subjects who fulfill inclusion criteria will be randomly assigned into the acupuncture group (AG) (n = 80) or control group (CG) (n = 80). AG will receive acupuncture treatment and perioperative care guided by ERAS protocols, and CG will only receive perioperative care guided by ERAS protocols. The intervention will begin on the first day post-surgery, continuing for 4 days, with a follow-up assessment in a month. Time of first postoperative flatus would be the primary outcome measure. Secondary outcome measures include the time of first postoperative defecation, time of first fluid intake, time of first ambulation, postoperative hospital stay, gastrointestinal reaction score, acupuncture sensation evaluation scale, laboratory tests, postoperative quality of life, readmission rate, and postoperative complications. All results are evaluated from baseline, post-treatment, and upon follow-up.

The results of the study would help elucidate evidence of the therapeutic effects of acupuncture on the recovery of postoperative gastrointestinal function. The objective of the study aims for the eventual inclusion of acupuncture in the ERAS protocol, allowing for wider application in clinical practice.

ClinicalTrials.gov ChiCTR2000036351. Registered on August 22, 2020

• Epac1–Piezo2 axis
• electroacupuncture
• irritable bowel syndrome
• somatic hypersensitivity
• visceral hypersensitivity

• Animals
• Electroacupuncture
• Guanine Nucleotide Exchange Factors/genetics
• Hyperalgesia/etiology
• Hyperalgesia/metabolism
• Hyperalgesia/therapy
• Ion Channels/genetics
• Irritable Bowel Syndrome/therapy
• Mice
• Serotonin/metabolism