Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy

Table 1 The top associated networks from ingenuity pathway analysis

Carbohydrate metabolism, small molecule biochemistry, cell signaling

Lipid metabolism, small molecule biochemistry, drug metabolism

Inflammatory response, cardiovascular system development and function, lymphoid tissue structure and development

Cellular function and maintenance, inflammatory response, cell-to-cell signaling and interaction

Cellular movement, hematological system development and function, immune cell trafficking

Table 2 The top biological functions identified by ingenuity pathway analysis and the number of genes involved

	# of genes
Diseases and disorders
Inflammatory disease	218
Inflammatory response	202
Immunological disease	195
Respiratory disease	126
Hematological disease	112
Molecular and cellular functions
Cellular growth and proliferation	230
Cell death	224
Cell-to-cell signaling and interaction	188
Cellular development	152
Physiological system development and function
Hematological system development/function	214
Immune cell trafficking	137
Hematopoiesis	126
Tissue morphology	105
Cell-mediated immune response	85