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Copyright ©2014 Baishideng Publishing Group Inc.
World J Diabetes. Jun 15, 2014; 5(3): 258-266
Published online Jun 15, 2014. doi: 10.4239/wjd.v5.i3.258
Table 1 Effects of hypoglycemic drugs on ischemic preconditioning
StudyModelDiabetic drugEffect
Animal studies
Gross et al[23], 1992DogsGlibenclamide (glyburide)Abolished
Toombs et al[50], 1993RabbitsGlibenclamideAbolished
Mocanu et al[47], 2001RatsGlimepiridePreserved
Maddock et al[51], 2004RatsGlibenclamideAbolished
GlimepiridePreserved
Hausenloy et al[61], 2013RatsGlimepiridePreserved
Ye et al[62], 2008RatsPioglitazonePreserved
Glibenclamide (glyburide)Abolished
GlimepiridePreserved
Horimoto et al[63], 2002RabbitsGlibenclamideAbolished
GlimepiridePreserved
Bose et al[69], 2005RatsNative sequenced human GLP-1Preserved
Zhu et al[73], 2011RatsPioglitazoneIPC mimic
Sasaki et al[74], 2007RatsPioglitazoneIPC mimic
Ahmed et al[75], 2011RatsPioglitazoneIPC mimic
Li et al[76], 2008RatsPioglitazonePreserved
Wynne et al[77], 2005RatsPioglitazoneIPC mimic
Sarraf et al[78], 2012PorcinePioglitazoneAbolished
RosiglitazoneAbolished
Human studies
Cleveland et al[52], 1997Atrial muscle trabeculaeGlibenclamide (glyburide)Abolished
Tomai et al[53], 1994HumanGlibenclamideAbolished
Klepzig et al[45], 1999HumanGlibenclamideAbolished
GlimepiridePreserved
Lee et al[54], 2002HumanGlibenclamideAbolished
Tomai et al[55], 1999HumanGlibenclamideAbolished
Ovünç[56], 2000HumanGlibenclamideAbolished
Ferreira et al[57], 2005HumanGlibenclamideAbolished
Bilinska et al[58], 2007HumanGlibenclamideAbolished
GliclazidePartially preserved
Bogaty et al[59], 1998HumanGlibenclamidePreserved
Correa et al[60], 1997HumanGlibenclamidePreserved
Loubani et al[64], 2005Right atrial appendagesGlibenclamideAbolished
GliclazidePreserved (but abolished in supratherapeutic concentrations)
Hueb et al[66], 2007HumanRepaglinideAbolished
Rahmi et al[70], 2013HumanRepaglinideAbolished
VildagliptinPreserved