Clinical significance of Ki-67 in patients with lung adenocarcinoma in situ complicated by type 2 diabetes

Table 1 Comparison of the clinical data among the groups

Group	Number of patients (male/female)	Age (years)	BMI (kg/m2)	Smoking (n)	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)
A	160 (80/80)	60.07 ± 10.47	25.1 ± 2.9	48	5.01 ± 1.11	1.64 ± 0.97	1.09 ± 0.46
B	200 (100/100)	61.40 ± 9.97	25.0 ± 3.1	60	4.69 ± 0.75b	1.27 ± 0.60b	1.18 ± 0.27
C	60 (30/30)	59.99 ± 10.32	25.2 ± 3.0	14	4.76 ± 1.12b	1.29 ± 0.60b	1.24 ± 0.28b

^bP < 0.01 vs group A.

Values are presented as the mean ± SD. Group A: Patients with acute ischemic stroke (AIS) and type 2 diabetes mellitus; Group B: Patients with AIS alone; Group C: Patients with benign pulmonary lesions. TC: Total cholesterol; TG: Total triglyceride; HDL-C: High-density lipoprotein cholesterol; BMI: Body mass index.

Table 2 Ki-67 expression among the three groups

Group	Number of patients	Negative (%)	Weakly positive (%)	Moderately positive (%)	Strongly positive (%)	Total positive rate (%)
A	160	21 (13.13)	60 (37.50)	42 (26.25)	37(23.13)	139 (86.87)
B	200	46 (23.00)	107 (53.50)b	24 (12.00)b	23 (11.50)b	154 (77.00)a
C	60	58 (96.67)	2 (3.33)b,d	0b,d	0b,d	2 (3.33)b,d

^aP < 0.05 vs group A.

^bP < 0.01 vs group A.

^dP < 0.01 vs group B.

Values are presented as the mean ± SD. Group A: Patients with acute ischemic stroke (AIS) and type 2 diabetes mellitus; Group B: Patients with AIS alone; Group C: Patients with benign pulmonary lesions.

Table 3 Logistic regression analysis of factors influencing the risk of adenocarcinoma in situ and type 2 diabetes mellitus

Independent variables	β	Standard error	Wald	OR (95%CI)	P value
Ki-67	−0.140	0.045	9.697	0.870 (0.796–0.950)	0.002
FPG	0.654	0.234	7.810	1.923 (1.216–3.043)	0.005
HbA1c	1.452	0.690	15.036	11.563 (2.165-12.016)	< 0.01
Insulin	−0.126	0.057	4.880	0.882 (0.788–0.986)	0.027
HDL-C	−3.151	1.151	7.495	0.043 (0.004–0.409)	0.006
TC	1.137	0.515	4.864	3.116 (1.135–8.556)	0.027
TG	0.054	0.405	0.018	1.056 (0.477–2.336)	0.893
LDL-C	0.377	0.381	0.978	1.458 (0.691–3.077)	0.323

FPG: Fasting plasma glucose; HbA₁c: Glycosylated hemoglobin; HDL-C: High-density lipoprotein cholesterol; TC: Total cholesterol; TG: Total triglyceride; LDL-C: Low-density lipoprotein cholesterol.