Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

Table 1 Comparison of weight loss effects, as well as blood pressure and blood glucose indicators among the patients (n = 78)

Time	Weight (kg)	BMI (kg/m2)	SBP (mmHg)	DBP (mmHg)	FBG (mmol/L)	PBG (mmol/L)	HbA1c (%)
Preoperative	69.5 ± 6.8	24.3 ± 2.3	150.9 ± 10.2	110.2 ± 9.2	10.5 ± 2.7	17.8 ± 2.6	9.2 ± 0.9
3 months postoperative	69.2 ± 6.1	24.1 ± 2.4	141.4 ± 8.2a	98.6 ± 8.1a	10.1 ± 1.6	12.8 ± 2.1a	8.1 ± 0.7a
6 months postoperative	67.4 ± 7.2a,b	23.1 ± 2.5a,b	135.2 ± 9.4b	86.4 ± 8.6b	7.2 ± 1.1a,b	9.8 ± 2.3b	7.1 ± 0.6b

^aP < 0.05 vs preoperative value.

^bP < 0.05 vs 3 months postoperative value.

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; FBG: Fasting blood glucose; PBG: Postprandial blood glucose; HbA1c: Hemoglobin A1c.

Table 2 Comparison of pancreatic islet function indicators among patients (n = 78)

Time	FCP (ng/mL)	PCP (ng/mL)	Fins (uIU/mL)	Pins (uIU/mL)	HOMA-IR	HOMA-β
Preoperative	1.1 ± 0.3	2.9 ± 0.4	16.8 ± 2.7	27.7 ± 3.6	7.7 ± 1.8	35.5 ± 5.2
3 months postoperative	1.1 ± 0.2	2.9 ± 0.5	16.9 ± 2.9	28.1 ± 2.7	7.9 ± 1.9	35.9 ± 4.9
6 months postoperative	1.2 ± 0.2	3.6 ± 0.4a,b	19.1 ± 2.3a,b	36.4 ± 2.9a,b	6.1 ± 0.8a,b	39.2 ± 4.1a,b

^aP < 0.05 vs preoperative value.

^bP < 0.05 vs 3 months postoperative value.

HOMA-β: β Cellular function index; FCP: Fasting c-peptide; PCP: Postprandial c-peptide; Fins: Fasting insulin; Pins: Postprandial insulin; HOMA-IR: Homeostasis model assessment of insulin resistance.

Table 3 Comparison of lipid and purine metabolic indicators among the patients (n = 78)

Time	ALT (U/L)	AST (U/L)	TC (mmol/L)	LDL-C (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	UA (µmol/L)
Preoperative	37. 1 ± 4.1	25.8 ± 3.6	5.2 ± 0.8	3.4 ± 0.7	4.2 ± 0.9	0.9 ± 0.08	410. 9 ± 35.1
3 months postoperative	38. 2 ± 3.1	24.6 ± 2.9	5.3 ± 0.7	2.6 ± 0.4a	2.7 ± 0.5a	1.0 ± 0.09	405. 2 ± 30.4
6 months postoperative	38. 9 ± 3.7	25.4 ± 2.2	4.2 ± 0.3a,b	2.5 ± 0.6a	2.0 ± 0.3b	1.0 ± 0.07	345. 2 ± 28.2a,b

^aP < 0.05 vs preoperative value.

^bP < 0.05 vs 3 months postoperative value.

ALT: Alanine transaminase; AST: Aspartate aminotransferase; TC: Total cholesterol; LDL-C: Low density lipoprotein cholesterol; TG: Triglyceride; HDL-C: High density lipoprotein cholesterol; UA: Uric acid.