Li JL, Zhao J, Guo ZF, Xiao C, Liu X. Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery. World J Diabetes 2024; 15(6): 1234-1241 [PMID: 38983819 DOI: 10.4239/wjd.v15.i6.1234]
Corresponding Author of This Article
Xuan Liu, MM, Doctor, Department of Ophthalmology, Xianyang First People’s Hospital, No. 10 Biyuan Road, Qindu District, Xianyang 712000, Shaanxi Province, China. lx641131366@126.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1234-1241 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1234
Table 1 General data, n (%)
Factors
Observation group (n = 42)
Control group (n = 40)
t/χ2
P value
Sex
0.001
0.991
Male
22 (52.38)
21 (52.50)
Female
20 (47.62)
19 (47.50)
Age (yr)
0.002
0.965
≤ 61
17 (40.48)
16 (40.00)
> 61
25 (59.52)
24 (60.00)
BMI (kg/m2)
0.001
0.983
≤ 23
23 (54.76)
22 (55.00)
> 23
19 (45.24)
18 (45.00)
Mean course of disease (months)
4.65 ± 0.85
4.82 ± 0.81
0.926
0.357
Hypertension
0.001
0.991
Yes
20 (47.62)
19 (47.50)
No
22 (52.38)
21 (52.50)
Smoking history
0.002
0.965
Yes
25 (59.52)
24 (60.00)
No
17 (40.48)
16 (40.00)
Table 2 Comparison of therapeutic efficacy, n (%)
Therapeutic effect
Observation group (n = 42)
Control group (n = 40)
χ2
P value
Cure
24 (57.14)
14 (35.00)
Marked effectiveness
10 (23.81)
10 (25.00)
-
-
Effectiveness
6 (14.29)
4 (10.00)
-
-
Ineffectiveness
2 (4.76)
12 (30.00)
-
-
Total effective rate
40 (95.24)
28 (70.00)
9.217
0.002
Table 3 Comparison of adverse reaction rates, n (%)
Adverse reactions
Observation group (n = 42)
Control group (n = 40)
χ2
P value
Conjunctival hyperemia
2 (4.76)
1 (2.50)
-
-
Aggravated lacrimal gland injury
1 (2.38)
1 (2.50)
-
-
Local inflammation
0
1 (2.50)
-
-
Corneal erosion
2 (4.76)
2 (5.00)
-
-
Adverse reaction rate
5 (11.90)
5 (12.50)
0.007
0.934
Table 4 Comparison of treatment satisfaction
Satisfaction
Observation group (n = 42)
Control group (n = 40)
χ2
P value
Very satisfied
30 (71.43)
19 (47.50)
-
-
Satisfied
11 (26.19)
10 (25.00)
-
-
Dissatisfied
1 (2.38)
11 (27.50)
-
-
Treatment satisfaction
41 (97.62)
29 (72.50)
10.35
0.001
Citation: Li JL, Zhao J, Guo ZF, Xiao C, Liu X. Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery. World J Diabetes 2024; 15(6): 1234-1241