Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

Table 1 Comparison of patients’ general data

	Research (n = 65)	Control (n = 60)	t/χ2	P value	95%CI
Sex (male/female)	39/26	40/20	0.5962	0.4400	0.3610 to 1.5580
Average age (yr)	64.66 ± 5.45	66.63 ± 6.15	1.6132	0.1093	-0.3856 to 3.8370
BMI (kg/m2)	22.39 ± 1.75	22.91 ± 1.84	1.6193	0.7079	-0.1081 to 1.1630
Course of diabetes mellitus (yr)	10.58 ± 1.95	10.68 ± 2.74	0.2365	0.8135	-1.1820 to 2.2130
NYHA grading of cardiac function			125.03	< 0.0001
I	0	60
II	19	0
III	25	0
IV	21	0
History of hypertension	30	25	0.2550	0.6136	0.5911 to 2.4360
Smoking history	32	23	1.5041	0.2201	0.7651 to 3.181

NYHA: New York Heart Association.

Table 2 Neutrophil-lymphocyte ratio and red blood cell distribution width levels in two groups

	NLR	RDW	LVEF (%)
Research (n = 65)	5.40 ± 1.79	16.00 ± 1.63	41.85 ± 7.23
Control (n = 60)	2.99 ± 0.98	13.88 ± 1.08	58.07 ± 6.79
t	9.2283	8.4976	12.9016
P value	< 0.0001	< 0.0001	< 0.0001
95%CI	-2.921 to -1.889	-2.619 to -1.629	13.73 to 18.71

NLR: Neutrophil-lymphocyte ratio; RDW: Red blood cell distribution width; LVEF: Left ventricular ejection fraction.

Table 3 Comparison of general data in research groups with different cardiac function grades

NYHA classification	n	Male	Age (mean ± SD)	Course of diabetes mellitus	NLR	RDW	LEVF (%)
II	19	8	62.79 ± 4.83	10.77 ± 1.83	3.91 ± 1.64	14.72 ± 1.25	45.82 ± 6.14
III	25	16	65.84 ± 5.81	10.30 ± 1.96	5.55 ± 1.31	15.53 ± 1.04	42.75 ± 5.94
IV	21	15	65.71 ± 6.25	10.75 ± 2.11	6.56 ± 1.48	17.72 ± 0.93	37.20 ± 7.23
F		3.8452	1.8600	0.4070	16.4300	42.7900	9.3240
P value		0.1463	0.1643	0.6674	< 0.0001	< 0.0001	0.0003

NYHA: New York Heart Association; NLR: Neutrophil-lymphocyte ratio; RDW: Red blood cell distribution width; LVEF: Left ventricular ejection fraction.

Table 4 Diagnostic efficiency of neutrophil-lymphocyte ratio and red blood cell distribution width

	AUC	SE	Specificity (%)	Sensitivity (%)	95%CI
NLR	0.864	0.033	90.0	75.4	0.799-0.929
RDW	0.859	0.034	86.7	76.9	0.793-0.925
Joint detection	0.915	0.027	100.0	76.9	0.863-0.968

NLR: Neutrophil-lymphocyte ratio; RDW: Red blood cell distribution width; AUC: The area under the receiver operating characteristic curve.

Table 5 Comparison of neutrophil-lymphocyte ratio and red blood cell distribution width levels in patients with or without cardiac events

	n	NLR	RDW
Without cardiac events	46	4.97 ± 1.66	15.70 ± 1.64
With cardiac events	19	6.45 ± .68	16.72 ± 1.42
t		3.2610	2.3540
P value		0.0018	0.0217

NLR: Neutrophil-lymphocyte ratio; RDW: Red blood cell distribution width.