Analysis of N6-methyladenosine-modified mRNAs in diabetic cataract

Table 1 Features of diabetic cataract patients included in microarray analysis

No.	Gender	Age (yr)	AL (mm)	Lens opacity grading	Duration of DM (year)	FBG (mmol/L)	HbA1c (%)
1	Male	64	22.09	C4N3P3	10	7.89	7.50
2	Female	68	21.77	C3N4P4	7	8.30	7.80
3	Female	63	23.43	C4N4P5	7	8.30	7.90

AL: Axial length; FBG: Fasting blooding glucose; HbA1c: Hemoglobin; DM: Diabetes mellitus.

Table 2 The top 20 most hyper- and hypomethylated mRNAs

Gene symbol	P value	Fold change	Regulation	Chromosome
AQP2	0.001135123	3.60	Hyper	chr12
RPL10	0.001594064	3.40	Hyper	chrX
ACP5	0.004544885	3.25	Hyper	chr19
ACAP1	0.003944032	3.21	Hyper	chr17
CALML6	0.00484061	3.05	Hyper	chr1
DDX31	1.02006E-05	3.04	Hyper	chr9
KRTAP29-1	3.59728E-05	2.97	Hyper	chr17
TRIM39-RPP21	0.001179594	2.95	Hyper	chr6
DGCR8	0.013600714	2.90	Hyper	chr22
LRAT	0.001067196	2.90	Hyper	chr4
NR1H3	0.028959935	5.78	Hypo	chr11
PNPT1	0.001479448	4.99	Hypo	chr2
TSEN2	0.015094744	4.99	Hypo	chr3
C3orf80	0.000939962	4.61	Hypo	chr3
TBCD	0.001813039	4.61	Hypo	chr17
RPS19	0.004668423	4.12	Hypo	chr19
TEAD2	0.031922173	4.02	Hypo	chr19
RAB3IP	0.005656491	3.96	Hypo	chr12
HN1L	0.008004647	3.77	Hypo	chr16
TFEB	0.004349132	3.70	Hypo	chr6